Abramson MA, Sexton DJ (1999) Nosocomial methicillin-resistant and methicillin-susceptible Staphylococcus aureus primary bacteremia: at what costs? Infect Control Hosp Epidemiol 20:408–411

Article  CAS  PubMed  Google Scholar 

Agerberth B, Charo J, Werr J, Olsson B, Idali F, Lindbom L, Kiessling R, Jornvall H, Wigzell H, Gudmundsson GH (2000) The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. Blood 96:3086–3093

Article  CAS  PubMed  Google Scholar 

Ahangarzadeh RM, Behzadiannezhad Q, Najjar-Pirayeh S and Oulia P (2002) In vitro activity of imipenem and ceftazidime against mucoid and non-mucoid strains of Pseudomonas aeruginosa isolated from patients in Iran. Arch Iran Med 4

Alcayaga-Miranda F, Cuenca J, Martin A, Contreras L, Figueroa FE, Khoury M (2015) Combination therapy of menstrual derived mesenchymal stem cells and antibiotics ameliorates survival in sepsis. Stem Cell Res Ther 6:199. https://doi.org/10.1186/s13287-015-0192-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barber M (1961) Methicillin-resistant staphylococci. J Clin Pathol 14:385–393. https://doi.org/10.1136/jcp.14.4.385

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cafferkey MT, Hone R, Coleman D, Pomeroy H, McGrath B, Ruddy R, Keane CT (1985) Methicillin-resistant Staphylococcus aureus in Dublin 1971–84. Lancet 2:705–708. https://doi.org/10.1016/s0140-6736(85)92942-3

Article  CAS  PubMed  Google Scholar 

Control CfD and Prevention (1997) Update: Staphylococcus aureus with reduced susceptibility to vancomycin–United States, 1997. MMWR Morb Mortal Wkly Rep 46:813

Google Scholar 

Diekema D, Pfaller M, Schmitz F, Smayevsky J, Bell J, Jones R, Beach M and Group SP (2001) Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillance Program, 1997–1999. Clin Infect Dis 32:S114–S132

Article  Google Scholar 

Driscoll JA, Brody SL, Kollef MH (2007) The epidemiology, pathogenesis and treatment of Pseudomonas aeruginosa infections. Drugs 67:351–368. https://doi.org/10.2165/00003495-200767030-00003

Article  CAS  PubMed  Google Scholar 

Duckworth GJ (1993) Diagnosis and management of methicillin resistant Staphylococcus aureus infection. BMJ 307:1049–1052. https://doi.org/10.1136/bmj.307.6911.1049

Article  CAS  PubMed  PubMed Central  Google Scholar 

Finnan S, Morrissey JP, O’Gara F, Boyd EF (2004) Genome diversity of Pseudomonas aeruginosa isolates from cystic fibrosis patients and the hospital environment. J Clin Microbiol 42:5783–5792. https://doi.org/10.1128/JCM.42.12.5783-5792.2004

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gelband H, Molly Miller P, Pant S, Gandra S, Levinson J, Barter D, White A, Laxminarayan R (2015) The state of the world’s antibiotics 2015. Wound Healing Southern Africa 8:30–34

Google Scholar 

Gofton TE, Young GB (2012) Sepsis-associated encephalopathy. Nat Rev Neurol 8:557–566. https://doi.org/10.1038/nrneurol.2012.183

Article  CAS  PubMed  Google Scholar 

Gudmundsson GH, Agerberth B, Odeberg J, Bergman T, Olsson B, Salcedo R (1996) The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. Eur J Biochem 238:325–332. https://doi.org/10.1111/j.1432-1033.1996.0325z.x

Article  CAS  PubMed  Google Scholar 

Gupta N, Krasnodembskaya A, Kapetanaki M, Mouded M, Tan X, Serikov V, Matthay MA (2012) Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia. Thorax 67:533–539. https://doi.org/10.1136/thoraxjnl-2011-201176

Article  PubMed  Google Scholar 

Hancock RE, Siehnel R, Martin N (1990) Outer membrane proteins of Pseudomonas. Mol Microbiol 4:1069–1075. https://doi.org/10.1111/j.1365-2958.1990.tb00680.x

Article  CAS  PubMed  Google Scholar 

Harman RM, Yang S, He MK, Van de Walle GR (2017) Antimicrobial peptides secreted by equine mesenchymal stromal cells inhibit the growth of bacteria commonly found in skin wounds. Stem Cell Res Ther 8:157

Article  PubMed  PubMed Central  Google Scholar 

Jarvis W, Gaynes R, Horan T, Alonso-Echanove J, Emori T, Fridkin S, Lawton R, Richards M, Wright G, Culver D (1998) National Nosocomial Infections Surveillance (NNIS) system report, data summary from October 1986 April 1998, issued June 1998. Am J Infect Control 26:522–533

Article  Google Scholar 

Kahlenberg JM, Kaplan MJ (2013) Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease. J Immunol 191:4895–4901. https://doi.org/10.4049/jimmunol.1302005

Article  CAS  PubMed  Google Scholar 

Karnatovskaia LV, Festic E (2012) Sepsis: a review for the neurohospitalist. Neurohospitalist 2:144–153. https://doi.org/10.1177/1941874412453338

Article  PubMed  PubMed Central  Google Scholar 

Kouhkheil R, Fridoni M, Piryaei A, Taheri S, Chirani AS, Anarkooli IJ, Nejatbakhsh R, Shafikhani S, Schuger LA, Reddy VB, Ghoreishi SK, Jalalifirouzkouhi R, Chien S, Bayat M (2018) The effect of combined pulsed wave low-level laser therapy and mesenchymal stem cell-conditioned medium on the healing of an infected wound with methicillin-resistant Staphylococcal aureus in diabetic rats. J Cell Biochem 119:5788–5797. https://doi.org/10.1002/jcb.26759

Article  CAS  PubMed  Google Scholar 

Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA (2010) Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cells 28:2229–2238

Article  CAS  PubMed  Google Scholar 

Lauth X, Babon JJ, Stannard JA, Singh S, Nizet V, Carlberg JM, Ostland VE, Pennington MW, Norton RS, Westerman ME (2005) Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections. J Biol Chem 280:9272–9282. https://doi.org/10.1074/jbc.M411154200

Article  CAS  PubMed  Google Scholar 

Li Z, Willke RJ, Pinto LA, Rittenhouse BE, Rybak MJ, Pleil AM, Crouch CW, Hafkin B, Glick HA (2001) Comparison of length of hospital stay for patients with known or suspected methicillin-resistant Staphylococcus species infections treated with linezolid or vancomycin: a randomized, multicenter trial. Pharmacotherapy 21:263–274. https://doi.org/10.1592/phco.21.3.263.34198

Article  CAS  PubMed  Google Scholar 

Maranan MC, Moreira B, Boyle-Vavra S, Daum RS (1997) Antimicrobial resistance in staphylococci. Epidemiology, molecular mechanisms, and clinical relevance. Infect Dis Clin North Am 11:813–849. https://doi.org/10.1016/s0891-5520(05)70392-5

Article  CAS  PubMed  Google Scholar 

Mezey É, Nemeth K (2015) Mesenchymal stem cells and infectious diseases: smarter than drugs. Immunol Lett 168:208–214

Article  CAS  PubMed  Google Scholar 

Minguell JJ, Erices A, Conget P (2001) Mesenchymal Stem Cells Exp Biol Med (maywood) 226:507–520. https://doi.org/10.1177/153537020122600603

Article  CAS  PubMed  Google Scholar 

Nahaei M, Bohloli Khiavi R, Asgarzadeh M, Hasani A, Sadeghi J, Akbari Dibavar M (2007) Antibiotic resistance and plasmid profiles of pseudomonas aeruginosa strains isolated from in-patients of sina hospital-tabriz. J Ardabil Univ Med Sci 7:90–98

Google Scholar 

Németh K, Leelahavanichkul A, Yuen PS, Mayer B, Parmelee A, Doi K, Robey PG, Leelahavanichkul K, Koller BH, Brown JM (2009) Bone marrow stromal cells attenuate sepsis via prostaglandin E 2–dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 15:42

Article  PubMed  Google Scholar 

Nimmo GR, Coombs GW, Pearson JC, O’Brien FG, Christiansen KJ, Turnidge JD, Gosbell IB, Collignon P, McLaws ML (2006) Methicillin-resistant Staphylococcus aureus in the Australian community: an evolving epidemic. Med J Aust 184:384–388. https://doi.org/10.5694/j.1326-5377.2006.tb00287.x

Article  PubMed  Google Scholar 

Qiao M, Ying GG, Singer AC, Zhu YG (2018) Review of antibiotic resistance in China and its environment. Environ Int 110:160–172. https://doi.org/10.1016/j.envint.2017.10.016

Article  CAS  PubMed  Google Scholar 

Rabani R, Volchuk A, Jerkic M, Ormesher L, Garces-Ramirez L, Canton J, Masterson C, Gagnon S, Tatham KC and Marshall J (2018) Mesenchymal stem cells enhance NOX2 dependent ROS production and bacterial killing in macrophages during sepsis. Eur Respir J 1702021

Rubin RJ, Harrington CA, Poon A, Dietrich K, Greene JA, Moiduddin A (1999) The economic impact of Staphylococcus aureus infection in New York City hospitals. Emerg Infect Dis 5:9–17. https://doi.org/10.3201/eid0501.990102

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saeedi P, Halabian R, Fooladi AAI (2019) Mesenchymal stem cells preconditioned by staphylococcal enterotoxin B enhance survival and bacterial clearance in murine sepsis model. Cytotherapy 21:41–53. https://doi.org/10.1016/j.jcyt.2018.11.002

Article  CAS  PubMed  Google Scholar 

Tyndall A, Pistoia V (2009) Mesenchymal stem cells combat sepsis. Nat Med 15:18–20. https://doi.org/10.1038/nm0109-18

Article  CAS  PubMed  Google Scholar 

Uccelli A, Moretta L, Pistoia V (2008) Mesenchymal stem cells in health and disease. Nat Rev Immunol 8:726–736. https://doi.org/10.1038/nri2395

Article  CAS  PubMed  Google Scholar 

Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Sakaguchi A, Ogawa H, Takamori K (2017) Effects of antimicrobial peptide LL-37 on expression of natural moisturizing factor-generating proteases in epidermal keratinocytes. J Dermatol Sci 86:e74–e75