Alharthi S, Popat A, Ziora ZM, Moyle PM (2023) Sortase A inhibitor protein nanoparticle formulations demonstrate antibacterial synergy when combined with antimicrobial peptides. Molecules 28(5):2114. https://doi.org/10.3390/molecules28052114
Article CAS PubMed PubMed Central Google Scholar
Atkins KL, Burman JD, Chamberlain ES et al (2008) S. aureus IgG-binding proteins SpA and Sbi: host specificity and mechanisms of immune complex formation. Mol Immunol 45(6):1600–1611. https://doi.org/10.1016/j.molimm.2007.10.021
Bae J, Jeon JE, Lee YJ, Lee HS, Sim CJ, Oh KB, Shin J (2011) Sesterterpenes from the tropical sponge Coscinoderma sp. J Nat Prod 74:1805–1811. https://doi.org/10.1021/np200492k
Article CAS PubMed Google Scholar
Becker S, Frankel MB, Schneewind O, Missiakas D (2014) Release of protein A from the cell wall of Staphylococcus aureus. Proc Natl Acad Sci USA 111(4):1574–1579. https://doi.org/10.1128/mBio.00575-13
Article CAS PubMed PubMed Central Google Scholar
Bekker H, Berendsen HJC, Dijkstra EJ et al (1993) Gromacs-a parallel computer for molecular-dynamics simulations. In: 4th International Conference on Computational Physics PC92. World Scientific Publishing, pp 252–256
Benov L (2019) Effect of growth media on the MTT colorimetric assay in bacteria. PLoS ONE 14(8):e0219713. https://doi.org/10.1371/journal.pone.0219713
Article CAS PubMed PubMed Central Google Scholar
Cascioferro S, Totsika M, Schillaci D (2014) Sortase A: an ideal target for anti-virulence drug development. Microb Pathog 77:105–112. https://doi.org/10.1016/j.micpath.2014.10.007
Article CAS PubMed Google Scholar
Chen F, Liu B, Wang D et al (2014) Role of sortase A in the pathogenesis of Staphylococcus aureus-induced mastitis in mice. FEMS Microbiol Lett 351(1):95–103. https://doi.org/10.1111/1574-6968.12354
Article CAS PubMed Google Scholar
De Jong NWM, Van Kessel KPM, Van Strijp JAG (2019) Immune evasion by Staphylococcus aureus. Microbiol Spectr 7(2). https://doi.org/10.1128/microbiolspec.GPP3-0061-2019
Dong J, Zhang L, Xu N, Zhou S, Song Y, Yang Q, Liu Y, Yang Y, Ai X (2021) Rutin reduces the pathogenicity of Streptococcus agalactiae to tilapia by inhibiting the activity of sortase A. Aquaculture 530:735743. https://doi.org/10.1016/j.aquaculture.2020.735743
Donlan RM (2001) Biofilm formation: a clinically relevant microbiological process. Clin Infect Dis 33(8):1387–1392. https://doi.org/10.1086/322972
Article CAS PubMed Google Scholar
Falugi F, Kim HK, Missiakas DM, Schneewind O (2013) Role of protein A in the evasion of host adaptive immune responses by Staphylococcus aureus. MBio 4(5):e00575–13. https://doi.org/10.1128/mBio.00575-13
Foster TJ, McDevitt D (1994) Surface-associated proteins of Staphylococcus aureus: their possible roles in virulence. FEMS Microbiol Lett 118(3):199–205. https://doi.org/10.1111/j.1574-6968.1994.tb06828.x
Article CAS PubMed Google Scholar
Gu K, Ding L, Wang Z et al (2023) Wogonin attenuates the pathogenicity of Streptococcus pneumoniae by double-target inhibition of Pneumolysin and Sortase A. J Cell Mol Med 27(4):563–575. https://doi.org/10.1111/jcmm.17684
Article CAS PubMed PubMed Central Google Scholar
Gupta A, Mahajan S, Sharma R (2015) Evaluation of antimicrobial activity of Curcuma longa rhizome extract against Staphylococcus aureus. Biotechnol Rep (Amst) 6:51–55. https://doi.org/10.1016/j.btre.2015.02.001
Hu P, Huang P, Chen MW (2013) Curcumin reduces Streptococcus mutans biofilm formation by inhibiting sortase A activity. Arch Oral Biol 58(10):1343–1348. https://doi.org/10.1016/j.archoralbio.2013.05.004
Jang KH, Chung SC, Shin J, Lee SH, Kim TI, Lee HS, Oh KB (2007) Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos. Bioorg Med Chem Lett 17:5366–5369. https://doi.org/10.1016/j.bmcl.2007.08.007
Article CAS PubMed Google Scholar
Jeon JE, Na Z, Jung M, Lee HS, Sim CJ, Nahm K, Oh KB, Shin J (2010) Discorhabdins from the Korean marine sponge Sceptrella sp. J Nat Prod 73:258–262. https://doi.org/10.1021/np9005629
Article CAS PubMed Google Scholar
Kang SS, Kim JG, Lee TH, Oh KB (2006) Flavonols inhibit sortases and sortase-mediated Staphylococcus aureus clumping to fibrinogen. Biol Pharm Bull 29:1751–1755. https://doi.org/10.1248/bpb.29.1751
Article CAS PubMed Google Scholar
Khatoon Z, McTiernan CD, Suuronen EJ, Mah TF, Alarcon EI (2018) Bacterial biofilm formation on implantable devices and approaches to its treatment and prevention. Heliyon 4(12):e01067. https://doi.org/10.1016/j.heliyon.2018.e01067
Article PubMed PubMed Central Google Scholar
Kim SH, Shin DS, Oh MN, Chung SC, Lee JS, Chang IM, Oh KB (2003) Inhibition of sortase, a bacterial surface protein anchoring transpeptidase, by β-sitosterol-3-O-glucopyranoside from Fritillaria verticillata. Biosci Biotechnol Biochem 67(11):2477–2479. https://doi.org/10.1271/bbb.67.2477
Article CAS PubMed Google Scholar
Kim SH, Shin DS, Oh MN, Chung SC, Lee JS, Oh KB (2004) Inhibition of the bacterial surface protein anchoring transpeptidase sortase by isoquinoline alkaloids. Biosci Biotechnol Biochem 68(2):421–424. https://doi.org/10.1271/bbb.68.421
Article CAS PubMed Google Scholar
Lee S, Song IH, Lee JH, Yang WY, Oh KB, Shin J (2014) Sortase A inhibitory metabolites from the roots of Pulsatilla koreana. Bioorg Med Chem Lett 24(1):44–48. https://doi.org/10.1016/j.bmcl.2013.12.006
Article CAS PubMed Google Scholar
Lee YJ, Han YR, Park W, Nam SH, Oh KB, Lee HS (2010) Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase. Bioorg Med Chem Lett 20(23):6882–6885. https://doi.org/10.1016/j.bmcl.2010.10.029
Article CAS PubMed Google Scholar
Li H, Chen Y, Zhang B et al (2016) Inhibition of sortase A by chalcone prevents Listeria monocytogenes infection. Biochem Pharmacol 106:19–29. https://doi.org/10.1016/j.bcp.2023.115447
Article CAS PubMed Google Scholar
Liu M, Lv Q, Xu J et al (2023) Isoflavone glucoside genistin, an inhibitor targeting Sortase A and Listeriolysin O, attenuates the virulence of Listeria monocytogenes in vivo and in vitro. Biochem Pharmacology 209:115447. https://doi.org/10.1016/j.bcp.2023.115447
Maggio B, Raffa D, Raimondi MV et al (2016) Discovery of a new class of sortase a transpeptidase inhibitors to tackle gram-positive pathogens: 2-(2-phenylhydrazinylidene) alkanoic acids and related derivatives. Molecules 21(2):241. https://doi.org/10.3390/molecules21020241
Article CAS PubMed PubMed Central Google Scholar
Marraffini LA, DeDent AC, Schneewind O (2006) Sortases and the art of anchoring proteins to the envelopes of gram-positive bacteria. Microbiol Mol Biol Rev 70(1):192–221. https://doi.org/10.1128/MMBR.70.1.192-221.2006
Article CAS PubMed PubMed Central Google Scholar
Mazmanian SK, Liu G, Ton-That H, Schneewind O (1999) Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall. Science 285(5428):760–763. https://doi.org/10.1126/science.285.5428.760
Article CAS PubMed Google Scholar
Menichetti F (2005) Current and emerging serious Gram-positive infections. Clin Microbiol Infect 11:22–28. https://doi.org/10.1111/j.1469-0691.2005.01138.x
Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS, Olson AJ (2009) AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility. J Comput Chem 30(16):2785–2791. https://doi.org/10.1002/jcc.21256
Article CAS PubMed PubMed Central Google Scholar
Mulcahy ME, McLoughlin RM (2016) Host–bacterial crosstalk determines Staphylococcus aureus nasal colonization. Trends Microbiol 24(11):872–886. https://doi.org/10.1016/j.tim.2016.06.012
Article CAS PubMed Google Scholar
Nitulescu G, Margina D, Zanfirescu A, Olaru OT, Nitulescu GM (2021) Targeting bacterial sortases in search of anti-virulence therapies with low risk of resistance development. Pharmaceuticals (Basel) 14(5):415. https://doi.org/10.3390/ph14050415
Nitulescu G, Mihai DP, Nicorescu IM, et al (2019) Discovery of natural naphthoquinones as sortase A inhibitors and potential anti-infective solutions against Staphylococcus aureus. Drug Dev Res 80(8):1136–1145. https://doi.org/10.1002/ddr.21599
Oh I, Yang WY, Chung SC, Kim TY, Oh KB, Shin J (2011) In vitro sortase A inhibitory and antimicrobial activity of flavonoids isolated from the roots of Sophora flavescens. Arch Pharm Res 34(2):217–222. https://doi.org/10.1007/s12272-011-0206-0
Article CAS PubMed Google Scholar
Oh KB, Kim SH, Lee J, Cho WJ, Lee T, Kim S (2004) Discovery of diarylacrylonitriles as a novel series of small molecule Sortase A inhibitors. J Med Chem 47(10):2418–2421. https://doi.org/10.1021/jm0498708
Article CAS PubMed Google Scholar
Oh KB, Mar W, Kim S et al (2005) Bis(indole) alkaloids as sortase A inhibitors from the sponge Spongosorites sp. Bioorg Med Chem Lett 15(22):4927–4931. https://doi.org/10.1016/j.bmcl.2005.08.021
Article CAS PubMed Google Scholar
O’Toole GA (2011) Microtiter dish biofilm formation assay. J Vis Exp 47:e2437. https://doi.org/10.3791/2437
Park BS, Kim JG, Kim MR, Lee SE, Takeoka GR, Oh KB, Kim JH (2005) Curcuma longa L. constituents inhibit sortase A and Staphylococcus aureus cell adhesion to fibronectin. J Agric Food Chem 53(23):9005–9009. https://doi.org/10.1021/jf051765z
Paterson GK, Mitchell TJ (2004) The biology of Gram-positive sortase enzymes. Trends Microbiol 12(2):89–95. https://doi.org/10.1016/j.tim.2003.12.007
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