Smoking and alcohol consumption with the risk of 11 common otolaryngological diseases: a bidirectional Mendelian randomization

Lugg ST, Scott A, Parekh D et al (2022) Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease. Thorax 771:94–101

Article  Google Scholar 

Messner B, Bernhard D (2014) Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis. Arterioscler Thromb Vasc Biol 343:509–515

Article  Google Scholar 

Rumgay H, Murphy N, Ferrari P et al (2021) Alcohol and cancer: epidemiology and biological mechanisms. Nutrients 13(9):3173

Hisinger-Mölkänen H, Piirilä P, Haahtela T et al (2018) Smoking, environmental tobacco smoke and occupational irritants increase the risk of chronic rhinitis. World Allergy Organ J 111:6

Article  Google Scholar 

Christensen DN, Franks ZG, McCrary HC et al (2018) A systematic review of the association between cigarette smoke exposure and chronic rhinosinusitis. Otolaryngol Head Neck Surg 1585:801–816

Article  Google Scholar 

Hsu WY, Chiu NY, Chang CC et al (2019) The association between cigarette smoking and obstructive sleep apnea. Tob Induc Dis 17:27

Article  PubMed  PubMed Central  Google Scholar 

Chang CP, Siwakoti B, Sapkota A et al (2020) Tobacco smoking, chewing habits, alcohol drinking and the risk of head and neck cancer in Nepal. Int J Cancer 1473:866–875

Article  Google Scholar 

Wan JY, Cataby C, Liem A et al (2020) Evidence for gene-smoking interactions for hearing loss and deafness in Japanese American families. Hear Res 387:107875

Article  CAS  PubMed  Google Scholar 

Yeo Y, Shin DW, Han K et al (2022) Smoking, alcohol consumption, and the risk of thyroid cancer: a population-based Korean cohort study of 10 million people. Thyroid 324:440–448

Article  Google Scholar 

Di Credico G, Polesel J, Dal Maso L et al (2020) Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration. Br J Cancer 1239:1456–1463

Article  Google Scholar 

Simou E, Britton J, Leonardi-Bee J (2018) Alcohol and the risk of sleep apnoea: a systematic review and meta-analysis. Sleep Med 42:38–46

Article  PubMed  PubMed Central  Google Scholar 

Qian P, Zhao Z, Liu S et al (2023) Alcohol as a risk factor for hearing loss: a systematic review and meta-analysis. PLoS ONE 181:e0280641

Article  Google Scholar 

Connor A, Emdin AVK, Kathiresan S (2017) Mendelian randomization. JAMA 31819:1925–1926

Google Scholar 

Skrivankova VW, Richmond RC, Woolf BAR et al (2021) Strengthening the reporting of observational studies in epidemiology using mendelian randomization: the STROBE-MR statement. JAMA 32616:1614–1621

Article  Google Scholar 

Davies NM, Holmes MV, Davey Smith G (2018) Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ 362:k601

Article  PubMed  PubMed Central  Google Scholar 

Hemani G, Zheng J, Elsworth B et al (2018) The MR-Base platform supports systematic causal inference across the human phenome. Elife https://doi.org/10.7554/eLife.34408

Burgess S, Thompson SG (2011) Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol 403:755–764

Article  Google Scholar 

Burgess S, Butterworth A, Thompson SG (2013) Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol 377:658–665

Article  Google Scholar 

Bowden J, Davey Smith G, Haycock PC et al (2016) Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol 404:304–314

Article  Google Scholar 

Bowden J, Davey Smith G, Burgess S (2015) Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol 442:512–525

Article  Google Scholar 

Cohen JF, Chalumeau M, Cohen R et al (2015) Cochran’s Q test was useful to assess heterogeneity in likelihood ratios in studies of diagnostic accuracy. J Clin Epidemiol 683:299–306

Article  Google Scholar 

Bowden J, Spiller W, Del Greco MF et al (2018) Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression. Int J Epidemiol 474:1264–1278

Article  Google Scholar 

Verbanck M, Chen CY, Neale B et al (2018) Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet 505:693–698

Article  Google Scholar 

Hutson K, Clark A, Hopkins C et al (2021) Evaluation of Smoking as a Modifying Factor in Chronic Rhinosinusitis. JAMA Otolaryngol Head Neck Surg 1472:159–165

Article  Google Scholar 

Di Credico G, Edefonti V, Polesel J et al (2019) Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: a bivariate spline model approach. Oral Oncol 94:47–57

Article  PubMed  PubMed Central  Google Scholar 

Cho A, Chang Y, Ahn J et al (2018) Cigarette smoking and thyroid cancer risk: a cohort study. Br J Cancer 1195:638–645

Article  Google Scholar 

Zhang Z, Li G, Yu L et al (2023) Causal relationships between potential risk factors and chronic rhinosinusitis: a bidirectional two-sample Mendelian randomization study. Eur Arch Otorhinolaryngol 2806:2785–2793

Article  Google Scholar 

Gormley M, Dudding T, Sanderson E et al (2020) A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer. Nat Commun 111:6071

Article  Google Scholar 

Hu H, Sasaki N, Ogasawara T et al (2019) Smoking, smoking cessation, and the risk of hearing loss: Japan epidemiology collaboration on occupational health study. Nicotine Tob Res 214:481–488

Article  Google Scholar 

Tarhun YM (2020) The effect of passive smoking on the etiology of serous otitis media in children. Am J Otolaryngol 413:102398

Article  Google Scholar 

Wang S, Qi L, Wei H et al (2022) Smoking behavior might affect allergic rhinitis and vasomotor rhinitis differently: a Mendelian randomization appraisal. World Allergy Organ J 152:100630

Article  Google Scholar 

Marziliano A, Teckie S, Diefenbach MA (2020) Alcohol-related head and neck cancer: Summary of the literature. Head Neck 424:732–738

Article  Google Scholar 

Koo HY, Han K, Shin DW et al (2021) Alcohol drinking pattern and risk of head and neck cancer: a nationwide cohort study. Int J Environ Res Public Health 18(21):11204

Denissoff A, Huusko T, Ventelä S et al (2022) Exposure to alcohol and overall survival in head and neck cancer: a regional cohort study. Head Neck 4410:2109–2117

Article  Google Scholar 

Lomholt FK, Nielsen SF, Nordestgaard BG (2016) High alcohol consumption causes high IgE levels but not high risk of allergic disease. J Allergy Clin Immunol 1385:1404-1413.e1413

Article  Google Scholar 

Skaaby T, Kilpeläinen TO, Taylor AE et al (2019) Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis. Addiction 1142:216–225

Article  Google Scholar 

Burgos-Sanchez C, Jones NN, Avillion M et al (2020) Impact of alcohol consumption on snoring and sleep apnea: a systematic review and meta-analysis. Otolaryngol Head Neck Surg 1636:1078–1086

Article  Google Scholar 

Kolla BP, Foroughi M, Saeidifard F et al (2018) The impact of alcohol on breathing parameters during sleep: a systematic review and meta-analysis. Sleep Med Rev 42:59–67

Article  PubMed  PubMed Central  Google Scholar 

De Schryver E, Derycke L, Campo P et al (2017) Alcohol hyper-responsiveness in chronic rhinosinusitis with nasal polyps. Clin Exp Allergy 472:245–253

Article  Google Scholar 

Hong SH, Myung SK, Kim HS (2017) Alcohol intake and risk of thyroid cancer: a meta-analysis of observational studies. Cancer Res Treat 492:534–547

Article  Google Scholar 

Sen A, Tsilidis KK, Allen NE et al (2015) Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study. Br J Cancer 1135:840–847

Article  Google Scholar 

Zong D, Liu X, Li J et al (2019) The role of cigarette smoke-induced epigenetic alterations in inflammation. Epigenetics Chromatin 121:65

Article  Google Scholar 

de la Iglesia JV, Slebos RJC, Martin-Gomez L et al (2020) Effects of tobacco smoking on the tumor immune microenvironment in head and neck squamous cell carcinoma. Clin Cancer Res 266:1474–1485

Article  Google Scholar 

Ferraguti G, Terracina S, Petrella C et al (2022) Alcohol and head and neck cancer: updates on the role of oxidative stress, genetic, epigenetics, oral microbiota, antioxidants, and alkylating agents. Antioxidants (Basel) 111:145

Rigotti NA, Kruse GR, Livingstone-Banks J et al (2022) Treatment of tobacco smoking: a review. JAMA 3276:566–577

Article  Google Scholar 

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