Long-acting interferon: pioneering disease modification of myeloproliferative neoplasms

1. Nangalia J, Green AR. Myeloproliferative neoplasms: from origins to outcomes. Blood 2017;130:2475–2483.
crossref pmid pdf
2. Hasselbalch HC, Holmström MO. Perspectives on interferon-alpha in the treatment of polycythemia vera and related myeloproliferative neoplasms: minimal residual disease and cure? Semin Immunopathol 2019;41:5–19.
crossref pmid pmc pdf
3. Jia R, Kralovics R. Progress in elucidation of molecular pathophysiology of myeloproliferative neoplasms and its application to therapeutic decisions. Int J Hematol 2020;111:182–191.
crossref pmid pdf
4. Byun JM, Bang SM, Choi EJ, et al. How myeloproliferative neoplasms patients’ experience and expectations differ from physicians’: the international MPN Landmark survey. Korean J Intern Med 2022;37:444–454.
crossref pmid pmc pdf
5. Song IC, Yeon SH, Lee MW, et al. Thrombotic and hemorrhagic events in 2016 World Health Organization-defined Philadelphia-negative myeloproliferative neoplasm. Korean J Intern Med 2021;36:1190–1203.
crossref pmid pmc pdf
6. Bacigalupo A, Innocenti I, Rossi E, et al. Allogeneic hemopoietic stem cell transplantation for myelofibrosis: 2021. Front Immunol 2021;12:637512.
crossref pmid pmc
7. Isaacs A, Lindenmann J. Virus interference. I. The interferon. Proc R Soc Lond B Biol Sci 1957;147:258–267.
crossref pmid pdf
8. Borden EC, Sen GC, Uze G, et al. Interferons at age 50: past, current and future impact on biomedicine. Nat Rev Drug Discov 2007;6:975–990.
crossref pmid pmc pdf
9. Kujawski LA, Talpaz M. The role of interferon-alpha in the treatment of chronic myeloid leukemia. Cytokine Growth Factor Rev 2007;18:459–471.
crossref pmid
10. Yoon SY, Won JH. The clinical role of interferon alpha in Philadelphia-negative myeloproliferative neoplasms. Blood Res 2021;56:S44–S50.
crossref pmid pmc
11. Gisslinger H, Klade C, Georgiev P, et al. S196: Ropeginterferon ALFA-2B achieves patient-specific treatment goals in polycythemia vera: final results from the Proud-PV/Continuation-PV studies. HemaSphere 2022;6:97–98.
crossref
12. Abu-Zeinah G, Krichevsky S, Cruz T, et al. Interferon-alpha for treating polycythemia vera yields improved myelofibrosis-free and overall survival. Leukemia 2021;35:2592–2601.
crossref pmid pmc pdf
13. Stein BL, Tiu RV. Biological rationale and clinical use of interferon in the classical BCR-ABL-negative myeloproliferative neoplasms. J Interferon Cytokine Res 2013;33:145–153.
crossref pmid
14. Chawla-Sarkar M, Lindner DJ, Liu YF, et al. Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis. Apoptosis 2003;8:237–249.
pmid
15. Saleiro D, Wen JQ, Kosciuczuk EM, et al. Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms. Nat Commun 2022;13:1750.
crossref pmid pmc pdf
16. Linkesch W, Gisslinger H, Ludwig H, Flener R, Sinzinger H. Therapy with interferon (recombinant IFN-alpha-2C) in myeloproliferative diseases with severe thrombocytoses. Acta Med Austriaca 1985;12:123–127German. 17. Ludwig H, Linkesch W, Gisslinger H, et al. Interferon-alfa corrects thrombocytosis in patients with myeloproliferative disorders. Cancer Immunol Immunother 1987;25:266–273.
crossref pmid pdf
18. Forsyth CJ, Chan WH, Grigg AP, et al. Recommendations for the use of pegylated interferon-α in the treatment of classical myeloproliferative neoplasms. Intern Med J 2019;49:948–954.
crossref pmid pdf
19. Mascarenhas J, Kosiorek HE, Prchal JT, et al. A randomized phase 3 trial of interferon-α vs hydroxyurea in polycythemia vera and essential thrombocythemia. Blood 2022;139:2931–2941.
crossref pmid pmc pdf
20. Baxter EJ, Scott LM, Campbell PJ, et al.; Cancer Genome Project. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 2005;365:1054–1061.
crossref pmid
21. Kiladjian JJ, Cassinat B, Turlure P, et al. High molecular response rate of polycythemia vera patients treated with pegylated interferon alpha-2a. Blood 2006;108:2037–2040.
crossref pmid
22. Kiladjian JJ, Klade C, Georgiev P, et al.; PROUD-PV Study Group. Long-term outcomes of polycythemia vera patients treated with ropeginterferon Alfa-2b. Leukemia 2022;36:1408–1411.
crossref pmid pmc pdf
23. Yacoub A, Mascarenhas J, Kosiorek H, et al. Pegylated interferon alfa-2a for polycythemia vera or essential thrombocythemia resistant or intolerant to hydroxyurea. Blood 2019;134:1498–1509.
crossref pmid pmc pdf
24. Sørensen AL, Mikkelsen SU, Knudsen TA, et al. Ruxolitinib and interferon-α2 combination therapy for patients with polycythemia vera or myelofibrosis: a phase II study. Haematologica 2020;105:2262–2272.
pmid pmc
25. Barbui T, Vannucchi AM, De Stefano V, et al. Ropeginterferon alfa-2b versus phlebotomy in low-risk patients with polycythaemia vera (Low-PV study): a multicentre, randomised phase 2 trial. Lancet Haematol 2021;8:e175–e184.
crossref pmid
26. Gisslinger H, Klade C, Georgiev P, et al.; PROUD-PV Study Group. Ropeginterferon alfa-2b versus standard therapy for polycythaemia vera (PROUD-PV and CONTINUATION-PV): a randomised, non-inferiority, phase 3 trial and its extension study. Lancet Haematol 2020;7:e196–e208.
crossref pmid
27. Ye J, Chen J. Interferon and hepatitis B: current and future perspectives. Front Immunol 2021;12:733364.
crossref pmid pmc
28. Verstovsek S, Komatsu N, Gill H, et al. SURPASS-ET: phase III study of ropeginterferon alfa-2b versus anagrelide as second-line therapy in essential thrombocythemia. Future Oncol 2022;18:2999–3009.
crossref pmid
29. Kralovics R, Passamonti F, Buser AS, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med 2005;352:1779–1790.
crossref pmid
30. Moliterno AR, Kaizer H, Reeves BN. JAK2 V617F allele burden in polycythemia vera: burden of proof. Blood 2023;141:1934–1942.
crossref pmid pmc pdf
31. Vannucchi AM, Antonioli E, Guglielmelli P, et al.; MPD Research Consortium. Prospective identification of high-risk polycythemia vera patients based on JAK2(V617F) allele burden. Leukemia 2007;21:1952–1959.
crossref pmid pdf
32. Guglielmelli P, Loscocco GG, Mannarelli C, et al. JAK2V617F variant allele frequency >50% identifies patients with polycythemia vera at high risk for venous thrombosis. Blood Cancer J 2021;11:199.
crossref pmid pmc pdf
33. Lee AJ, Kim SG, Nam JY, Yun J, Ryoo HM, Bae SH. Clinical features and outcomes of JAK2 V617F-positive polycythemia vera and essential thrombocythemia according to the JAK2 V617F allele burden. Blood Res 2021;56:259–265.
crossref pmid pmc
34. DePass LR, Weaver EV. Comparison of teratogenic effects of aspirin and hydroxyurea in the Fischer 344 and Wistar strains. J Toxicol Environ Health 1982;10:297–305.
crossref pmid
35. Adlard BP, Dobbing J. Maze learning by adult rats after inhibition of neuronal multiplication in utero. Pediatr Res 1975;9:139–142.
crossref pmid
36. Gangat N, Tefferi A. Myeloproliferative neoplasms and pregnancy: overview and practice recommendations. Am J Hematol 2021;96:354–366.
crossref pmid pdf
37. Antonioli E, Guglielmelli P, Pieri L, et al.; AGIMM Investigators. Hydroxyurea-related toxicity in 3,411 patients with Ph’-negative MPN. Am J Hematol 2012;87:552–554.
crossref pmid
38. Alvarez-Larrán A, Kerguelen A, Hernández-Boluda JC, et al.; Grupo Español de Enfermedades Mieloproliferativas Filadelfia Negativas (GEMFIN). Frequency and prognostic value of resistance/intolerance to hydroxycarbamide in 890 patients with polycythaemia vera. Br J Haematol 2016;172:786–793.
crossref pmid
39. Alvarez-Larrán A, Pereira A, Cervantes F, et al. Assessment and prognostic value of the European LeukemiaNet criteria for clinicohematologic response, resistance, and intolerance to hydroxyurea in polycythemia vera. Blood 2012;119:1363–1369.
crossref pmid pdf
40. Verstovsek S, Vannucchi AM, Griesshammer M, et al. Ruxolitinib versus best available therapy in patients with polycythemia vera: 80-week follow-up from the RESPONSE trial. Haematologica 2016;101:821–829.
crossref pmid pmc
41. Sever M, Newberry KJ, Verstovsek S. Therapeutic options for patients with polycythemia vera and essential thrombocythemia refractory/resistant to hydroxyurea. Leuk Lymphoma 2014;55:2685–2690.
crossref pmid pmc
42. Alvarez-Larrán A, Díaz-González A, Such E, et al.; MPN Spanish Group (GEMFIN). Genomic characterization of patients with polycythemia vera developing resistance to hydroxyurea. Leukemia 2021;35:623–627.
crossref pmid pmc pdf
43. Bartels S, Faisal M, Büsche G, Schlue J, Kreipe H, Lehmann U. Fibrotic progression in Polycythemia vera is associated with early concomitant driver-mutations besides JAK2. Leukemia 2018;32:556–558.
crossref pmid pdf
44. Cerquozzi S, Tefferi A. Blast transformation and fibrotic progression in polycythemia vera and essential thrombocythemia: a literature review of incidence and risk factors. Blood Cancer J 2015;5:e366.
crossref pmid pmc pdf
45. Qin A, Urbanski RW, Yu L, Ahmed T, Mascarenhas J. An alternative dosing strategy for ropeginterferon alfa-2b may help improve outcomes in myeloproliferative neoplasms: an overview of previous and ongoing studies with perspectives on the future. Front Oncol 2023;13:1109866.
crossref pmid pmc
46. Daltro De Oliveira R, Soret-Dulphy J, Zhao LP, et al. Interferon-alpha (IFN) therapy discontinuation is feasible in myeloproliferative neoplasm (MPN) patients with complete hematological remission. Blood 2020;136(Supplement 1):35–36.
crossref pdf
47. Utke Rank C, Weis Bjerrum O, Larsen TS, et al. Minimal residual disease after long-term interferon-alpha2 treatment: a report on hematological, molecular and histomorphological response patterns in 10 patients with essential thrombocythemia and polycythemia vera. Leuk Lymphoma 2016;57:348–354.
crossref pmid
48. Tefferi A, Guglielmelli P, Larson DR, et al. Long-term survival and blast transformation in molecularly annotated essential thrombocythemia, polycythemia vera, and myelofibrosis. Blood 2014;124:2507–2513quiz 2615.
crossref pmid pmc pdf
49. Abu-Zeinah K, Saadeh K, Silver RT, Scandura JM, Abu-Zeinah G. Excess mortality in younger patients with myeloproliferative neoplasms. Leuk Lymphoma 2023;64:725–729.
crossref pmid
50. Goulart H, Mascarenhas J, Tremblay D. Low-risk polycythemia vera and essential thrombocythemia: management considerations and future directions. Ann Hematol 2022;101:935–951.
crossref pmid pdf
51. Yoon SY, Won JH. Novel therapeutic strategies for essential thrombocythemia/polycythemia vera. Blood Res 2023;58(S1):83–89.
crossref pmid pmc
52. Quintás-Cardama A, Abdel-Wahab O, Manshouri T, et al. Molecular analysis of patients with polycythemia vera or essential thrombocythemia receiving pegylated interferon α-2a. Blood 2013;122:893–901.
crossref pmid pmc pdf

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