M Solangi: Design, methodology, synthesis, data acquisition, characterization of target compounds, ADMET studies and manuscript writing. KM Khan: Conceptualization, overall supervision of the whole project, formal analysis, review, editing, funding acquisition and authentication of the final draft of the manuscript. X Ji: Project co-supervision, formal analysis and writing of the original draft. M Özil and N Baltaş: Performed in vitro bioactivities and kinetics studies of all compounds. U Salar: Validation of characterization of spectral data and initial draft of the manuscript. A Khan and Z Ul-Haq: Performed in silico studies of the compounds. H Meghwar: Synthesis and data acquisition of compounds. M Taha: Involved in the conceptualization of this research work and the finalization of the manuscript.