U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for Americans. 2020–2025.
Fuchs FD, Whelton PK. High blood pressure and cardiovascular disease. Hypertension. 2020;75(2):285–92.
Article CAS PubMed Google Scholar
Tsao CW, et al. Heart disease and stroke statistics-2023 update: a report from the american heart association. Circulation. 2023;147(8):e93–621.
Xu J, et al. Mortality in the United States, 2021. NCHS Data Brief. 2022;456:1–8.
Elijovich F, et al. Salt sensitivity of blood pressure. Hypertension. 2016;68(3):e7–46.
Article CAS PubMed Google Scholar
Barba G, et al. Incidence of hypertension in individuals with different blood pressure salt-sensitivity: results of a 15-year follow-up study. J Hypertens. 2007;25(7):1465–71.
Article CAS PubMed Google Scholar
Morimoto A, et al. Sodium sensitivity and cardiovascular events in patients with essential hypertension. Lancet. 1997;350(9093):1734–7.
Article CAS PubMed Google Scholar
Weinberger MH, et al. Salt sensitivity, pulse pressure, and death in normal and hypertensive humans. Hypertension. 2001;37(2 Pt 2):429–32.
Article CAS PubMed Google Scholar
• Linder BA, et al. Short-term high salt intake does not influence resting or exercising heart rate variability but increases MCP-1 concentration in healthy young adults. Am J Physiol Regul Integr Comp Physiol. 2023;324(5):R666–76. This paper from our group highlights the influence of short-term high dietary salt on an inflammatory biomarker, plasma monocyte chemoattractant protein 1.
Article CAS PubMed Google Scholar
Barnett AM, et al. High dietary salt intake increases urinary NGAL excretion and creatinine clearance in healthy young adults. Am J Physiol Renal Physiol. 2022.
Babcock MC, et al. High salt intake augments blood pressure responses during submaximal aerobic exercise. J Am Heart Assoc. 2020;9(10).
Overlack A, et al. Age is a major determinant of the divergent blood pressure responses to varying salt intake in essential hypertension. Am J Hypertens. 1995;8(8):829–36.
Article CAS PubMed Google Scholar
Dengel DR, et al. Effect of aerobic exercise training on blood pressure sensitivity to dietary sodium in older hypertensives. J Hum Hypertens. 2006;20(5):372–8.
Article CAS PubMed Google Scholar
Svetkey LP, McKeown SP, Wilson AF. Heritability of salt sensitivity in Black Americans. Hypertension. 1996;28(5):854–8.
Article CAS PubMed Google Scholar
Elijovich F, et al. Salt sensitivity of blood pressure: a scientific statement from the American Heart Association. Hypertension. 2016;68(3):e7–46.
Article CAS PubMed Google Scholar
Sacks FM, DASH-Sodium Collaborative Research Group, et al. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. N Engl J Med. 2001;344(1):3–10.
Article CAS PubMed Google Scholar
Vollmer WM, et al. Effects of diet and sodium intake on blood pressure: subgroup analysis of the DASH-sodium trial. Ann Intern Med. 2001;135(12):1019–28.
Article CAS PubMed Google Scholar
Morris RC, et al. Normotensive salt sensitivity. Hypertension. 1999;33(1):18–23.
Article CAS PubMed Google Scholar
Schmidlin O, et al. NaCl-induced renal vasoconstriction in salt-sensitive African Americans. Hypertension. 1999;33(2):633–9.
Article CAS PubMed Google Scholar
• Hunter SD, Kavouras SA, Rahimi M. Exploring heated exercise as a means of preventing the deleterious effects of high-sodium intake in Black women. Am J Physiol Heart Circ Physiol. 2023;324(6):H833-h839. This paper highlights the influence of exercise, specifically hot yoga, and high dietary salt on endothelial function in Black female adults.
Article CAS PubMed Google Scholar
Luft FC, et al. Cardiovascular and humoral responses to extremes of sodium intake in normal black and white men. Circulation. 1979;60(3):697–706.
Article CAS PubMed Google Scholar
Dimsdale JE, et al. Prediction of salt sensitivity. Am J Hypertens. 1990;3(6 Pt 1):429–35.
Article CAS PubMed Google Scholar
Robinson AT, Wenner MM, Charkoudian N. Differential influences of dietary sodium on blood pressure regulation based on race and sex. Auton Neurosci. 2021;236:102873.
Article PubMed PubMed Central Google Scholar
Sudhir K, et al. Reduced dietary potassium reversibly enhances vasopressor response to stress in African Americans. Hypertension. 1997;29(5):1083–90.
Article CAS PubMed Google Scholar
He FJ, et al. Importance of the renin system in determining blood pressure fall with salt restriction in Black and White hypertensives. Hypertension. 1998;32(5):820–4.
Article CAS PubMed Google Scholar
Falkner B, Kushner H. Effect of chronic sodium loading on cardiovascular response in young Blacks and Whites. Hypertension. 1990;15(1):36–43.
Article CAS PubMed Google Scholar
JT Wright, et al. Determinants of salt sensitivity in Black and White normotensive and hypertensive women. Hypertension (Dallas, Tex. : 1979). 2003;42(6).
Appel LJ, et al. Effects of reduced sodium intake on hypertension control in older individuals. Arch Intern Med. 2001;161(5):685.
Article CAS PubMed Google Scholar
Palacios C, et al. Sodium retention in Black and White female adolescents in response to salt intake. J Clin Endocrinol Metab. 2004;89(4):1858–63.
Article CAS PubMed Google Scholar
He FJ, et al. Effect of modest salt reduction on blood pressure, urinary albumin, and pulse wave velocity in White, Black, and Asian mild hypertensives. Hypertension. 2009;54(3):482–8.
Article CAS PubMed Google Scholar
Kurtz TW, et al. No evidence of racial disparities in blood pressure salt sensitivity when potassium intake exceeds levels recommended in the US dietary guidelines. Am J Physiol Heart Circ Physiol. 2021;320(5):H1903-h1918.
Article CAS PubMed PubMed Central Google Scholar
• Ferguson JF, et al. High dietary salt–induced DC activation underlies microbial dysbiosis-associated hypertension. JCI Insight. 2019;4(13). This paper observed immune cell activation induced by high dietary salt and its association with gut dysbiosis in humans and mice.
Nichols OI, et al. Neighborhood socioeconomic deprivation in early childhood mediates racial disparities in blood pressure in a college student sample. J Youth Adolesc. 2022.
Grosicki GJ, et al. Acute beetroot juice reduces blood pressure in young Black and White males but not females. Redox Biol. 2023;63:102718.
Article CAS PubMed PubMed Central Google Scholar
Voors AW, et al. Studies of blood pressures in children, ages 5–14 years, in a total biracial community: the Bogalusa Heart Study. Circulation. 1976;54(2):319–27.
Article CAS PubMed Google Scholar
• Caraballo C, et al. Excess mortality and years of potential life lost among the Black Population in the US, 1999–2020. JAMA. 2023;329(19):1662–70. This paper reported data from the Centers for Disease Control over the recent 22-year period comparing excess death and years of life lost between the Black and White populations.
Rao S, et al. Association of genetic West African ancestry, blood pressure response to therapy, and cardiovascular risk among self-reported Black individuals in the systolic blood pressure reduction intervention trial (SPRINT). JAMA Cardiol. 2020.
Haas AV, et al. Genetic predictors of salt sensitivity of blood pressure: the additive impact of 2 hits in the same biological pathway. Hypertension. 2021;78(6):1809–17.
Article CAS PubMed Google Scholar
Grosicki GJ, et al. Racial and ethnic disparities in cardiometabolic disease and COVID-19 outcomes in White, Black/African American, and Latinx populations: social determinants of health. Prog Cardiovasc Dis. 2022;71:4–10.
Article PubMed PubMed Central Google Scholar
Robinson AT, Cook MD, Lane-Cordova AD. Making cell culture more physiological: a call for more a comprehensive assessment of racial disparities in endothelial cell culture studies. Am J Physiol Cell Physiol. 2019.
Kirkman D, et al. Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness and cardiovascular diseases. Am J Physiol Heart Circ Physiol. 2021.
Green DJ, et al. Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter? Hypertension. 2011;57(3):363–9.
Article CAS PubMed Google Scholar
Golia E, et al. Inflammation and cardiovascular disease: from pathogenesis to therapeutic target. Curr Atheroscler Rep. 2014;16(9).
Sessa WC. eNOS at a glance. J Cell Sci. 2004;117(Pt 12):2427–9.
Article CAS PubMed Google Scholar
Cook NR, et al. Sodium and health-concordance and controversy. BMJ. 2020;369:m2440.
Article PubMed PubMed Central Google Scholar
Watso JC, et al. The damaging duo: obesity and excess dietary salt contribute to hypertension and cardiovascular disease. Obes Rev. 2023;24(8):e13589.
Robinson AT, Edwards DG, Farquhar WB. The influence of dietary salt beyond blood pressure. Curr Hypertens Rep. 2019;21(6):42.
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