Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66(2):115–32. https://doi.org/10.3322/caac.21338.
Jiang D, Li X, Wang H, et al. The prognostic value of EGFR overexpression and amplification in Esophageal squamous cell Carcinoma. BMC Cancer. 2015;15:377. https://doi.org/10.1186/s12885-015-1393-8.
Article CAS PubMed PubMed Central Google Scholar
Gu ZD, Li JY, Li M, et al. Matrix metalloproteinases expression correlates with survival in patients with esophageal squamous cell carcinoma. Am J Gastroenterol. 2005;100(8):1835–43. https://doi.org/10.1111/j.1572-0241.2005.50018.x. Erratum in: Am J Gastroenterol. 2006 Sep;101(9):2171.
Article CAS PubMed Google Scholar
Song Y, Li L, Ou Y, et al. Identification of genomic alterations in oesophageal squamous cell cancer. Nature. 2014;509(7498):91–5. https://doi.org/10.1038/nature13176.
Article CAS PubMed Google Scholar
Brenner B, Purim O, Gordon N, et al. The addition of cetuximab to preoperative chemoradiotherapy for locally advanced esophageal squamous cell carcinoma is associated with high rate of long term survival: Mature results from a prospective phase Ib/II trial. Radiother Oncol. 2019;134:74–80. https://doi.org/10.1016/j.radonc.2019.01.013.
Article CAS PubMed Google Scholar
Sakaguchi S, Vignali DA, Rudensky AY, et al. The plasticity and stability of regulatory T cells. Nat Rev Immunol. 2013;13(6):461–7. https://doi.org/10.1038/nri3464.
Article CAS PubMed Google Scholar
Luo Q, Zhang S, Wei H, et al. Roles of Foxp3 in the occurrence and development of cervical cancer. Int J Clin Exp Pathol. 2015;8(8):8717–30.
PubMed PubMed Central Google Scholar
Zhu J, Li Z, Chen J, et al. A comprehensive bioinformatics analysis of FOXP3 in nonsmall cell lung cancer. Medicine. 2022;101(50):e32102. https://doi.org/10.1097/MD.0000000000032102.
Article CAS PubMed PubMed Central Google Scholar
Sun X, Feng Z, Wang Y, et al. Expression of Foxp3 and its prognostic significance in colorectal cancer. Int J Immunopathol Pharmacol. 2017;30(2):201–6. https://doi.org/10.1177/0394632017710415.
Article CAS PubMed PubMed Central Google Scholar
Zhang B, Dou Y, Xu X, et al. Endogenous FOXP3 inhibits cell proliferation, migration and invasion in glioma cells. Int J Clin Exp Med. 2015;8(2):1792–802.
PubMed PubMed Central Google Scholar
Wu L, Yi B, Wei S, et al. Loss of FOXP3 and TSC1 accelerates prostate cancer progression through synergistic transcriptional and posttranslational regulation of c‑MYC. Cancer Res. 2019;79(7):1413–25. https://doi.org/10.1158/0008-5472.CAN-18-2049.
Article CAS PubMed PubMed Central Google Scholar
Liu C, Han J, Li X, et al. FOXP3 inhibits the metastasis of breast cancer by downregulating the expression of MTA1. Front Oncol. 2021;11:656190. https://doi.org/10.3389/fonc.2021.656190.
Article CAS PubMed PubMed Central Google Scholar
Wang S, Zhang Y, Wang Y, et al. Amphiregulin confers regulatory T cell suppressive function and tumor invasion via the EGFR/GSK-3β/Foxp3 axis. J Biol Chem. 2016;291(40):21085–95. https://doi.org/10.1074/jbc.M116.717892.
Article CAS PubMed PubMed Central Google Scholar
Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 2003;4(4):330–6. https://doi.org/10.1038/ni904.
Article CAS PubMed Google Scholar
Sakaguchi S, Miyara M, Costantino CM, et al. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol. 2010;10(7):490–500. https://doi.org/10.1038/nri2785.
Article CAS PubMed Google Scholar
Xue L, Lu HQ, He J, et al. Expression of FOXP3 in esophageal squamous cell carcinoma relating to the clinical data. Dis Esophagus. 2010;23(4):340–6. https://doi.org/10.1111/j.1442-2050.2009.01013.x.
Article CAS PubMed Google Scholar
Wang G, Liu G, Liu Y, et al. FOXP3 expression in esophageal cancer cells is associated with poor prognosis in esophageal cancer. Hepatogastroenterology. 2012;59(119):2186–91. https://doi.org/10.5754/hge11961.
Li C, Yang W, Gai X, Zhang Y, et al. Foxp3 overexpression decreases sensitivity to chemotherapy in mouse Lewis lung cancer cells. Mol Med Rep. 2012;6(5):977–82. https://doi.org/10.3892/mmr.2012.1066.
Article CAS PubMed Google Scholar
Wang G, Sun Y, Ji C, et al. Correlation between the CD4+CD25high regulatory T cells and the outcome of chemotherapy in advanced esophageal carcinoma. Hepatogastroenterology. 2013;60(124):704–8. https://doi.org/10.5754/hge12953.
Article CAS PubMed Google Scholar
Xu T, Duan Q, Wang G, et al. CD4 + CD25high regulatory T cell numbers and FOXP3 mRNA expression in patients with advanced esophageal cancer before and after chemotherapy. Cell Biochem Biophys. 2011;61(2):389–92. https://doi.org/10.1007/s12013-011-9197-1.
Article CAS PubMed Google Scholar
Li C, Sun L, Jiang R, et al. Downregulation of FOXP3 inhibits cell proliferation and enhances chemosensitivity to cisplatin in human lung adenocarcinoma. Pathol Res Pract. 2017;213(10):1251–6. https://doi.org/10.1016/j.prp.2017.09.004.
Article CAS PubMed Google Scholar
Tanaka A, Nishikawa H, Noguchi S, et al. Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells. J Exp Med. 2020;217(2):e20191009. https://doi.org/10.1084/jem.20191009.
Article CAS PubMed Google Scholar
Isomoto K, Haratani K, Hayashi H, et al. Impact of EGFR-TKI Treatment on the Tumor Immune Microenvironment in EGFR Mutation-Positive Non-Small Cell Lung Cancer. Clin Cancer Res. 2020;26(8):2037–46. https://doi.org/10.1158/1078-0432.CCR-19-2027.
Article CAS PubMed Google Scholar
Sacco AG, Chen R, Worden FP, et al. Pembrolizumab plus cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma: an open-label, multi-arm, non-randomised, multicentre, phase 2 trial. Lancet Oncol. 2021;22(6):883–92. https://doi.org/10.1016/S1470-2045(21)00136-4.
Article CAS PubMed Google Scholar
Chung CH, Li J, Steuer CE, et al. Phase II multi-institutional clinical trial result of concurrent cetuximab and nivolumab in recurrent and/or metastatic head and neck squamous cell carcinoma. Clin Cancer Res. 2022;28(11):2329–38. https://doi.org/10.1158/1078-0432.CCR-21-3849.
Article CAS PubMed PubMed Central Google Scholar
Ito M, Komai K, Mise-Omata S, et al. Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery. Nature. 2019;565(7738):246–50. https://doi.org/10.1038/s41586-018-0824-5.
Article CAS PubMed Google Scholar
Jiang R, Tang J, Chen Y, et al. The long noncoding RNA lnc-EGFR stimulates T‑regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion. Nat Commun. 2017;8:15129. https://doi.org/10.1038/ncomms15129.
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