Pre-medication with simethicone and N-acetyl cysteine for improving mucosal visibility during upper gastrointestinal endoscopy: A randomized controlled trial

Beg S, Ragunath K, Wyman, A et al. Quality standards in upper gastrointestinal endoscopy: a position statement of the British Society of Gastroenterology (BSG) and Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS). Gut. 2017;66:1886–99.

Chiu PWY, Uedo N, Singh R, et al. An Asian consensus on standards of diagnostic upper endoscopy for neoplasia. Gut. 2019;68:186–97.

Article  PubMed  Google Scholar 

Asl SM, Sivandzadeh GR. Efficacy of premedication with activated dimethicone or N-acetylcysteine in improving visibility during upper endoscopy. World J Gastroenterol. 2011;17:4213–7.

Article  PubMed  PubMed Central  Google Scholar 

Monrroy H, Vargas JI, Glasinovic E, et al. Use of N-acetylcysteine plus simethicone to improve mucosal visibility during upper GI endoscopy: a double-blind, randomized controlled trial. Gastrointest Endosc. 2018;87:986–93.

Article  PubMed  Google Scholar 

Chang WK, Yeh MK, Hsu HC, Chen HW, Hu MK. Efficacy of simethicone and N-acetylcysteine as premedication in improving visibility during upper endoscopy. J Gastroenterol Hepatol. 2014;29:769–74.

Article  CAS  PubMed  Google Scholar 

Elvas L, Areia M, Brito D, Alves S, Saraiva S, Cadime AT. Premedication with simethicone and N-acetylcysteine in improving visibility during upper endoscopy: a double-blind randomized trial. Endoscopy. 2017;49:139–45.

PubMed  Google Scholar 

Schulz KF, Altman DG, Moher D, Group C. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ. 2010;340:c332.

Kuo CH, Sheu BS, Kao AW, Wu CH, Chuang CH. A defoaming agent should be used with pronase premedication to improve visibility in upper gastrointestinal endoscopy. Endoscopy. 2002;34:531–4.

Article  CAS  PubMed  Google Scholar 

Chang CC, Chen SH, Lin CP, et al. Premedication with pronase or N-acetylcysteine improves visibility during gastroendoscopy: an endoscopist-blinded, prospective, randomized study. World J Gastroenterol. 2007;13:444–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang LY, Li WY, Ji M, et al. Efficacy and safety of using premedication with simethicone/Pronase during upper gastrointestinal endoscopy examination with sedation: a single center, prospective, single blinded, randomized controlled trial. Dig Endosc. 2018;30:57–64.

Article  CAS  PubMed  Google Scholar 

Mahawongkajit P, Kanlerd A. A prospective randomized controlled trial comparing simethicone, N-acetylcysteine, sodium bicarbonate and peppermint for visualization in upper gastrointestinal endoscopy. Surg Endosc. 2021;35:303–8.

Article  PubMed  Google Scholar 

Neale JR, James S, Callaghan J, Patel P. Premedication with N-acetylcysteine and simethicone improves mucosal visualization during gastroscopy: a randomized, controlled, endoscopist-blinded study. Eur J Gastroenterol Hepatol. 2013;25:778–83.

Article  CAS  PubMed  Google Scholar 

Manfredi G, Berte R, Iiritano E, et al. Premedication with simethicone and N-acetylcysteine for improving mucosal visibility during upper gastrointestinal endoscopy in a Western population. Endosc Int Open. 2021;9:E190–4.

Article  PubMed  PubMed Central  Google Scholar 

Fuentes-Valenzuela E, Perez-Arenas E, de Benito Sanz M, et al. Prospective cohort study evaluating premedication with simethicone and n-acetilcysteine for upper diagnostic gastrointestinal endoscopy. Rev Esp Enferm Dig. 2023;115:10–5.

Anikhindi SA, Kumar A, Uedo N, et al. Pre-endoscopy drink of simethicone and n-acetylcysteine significantly improves visualization in upper gastrointestinal endoscopy. J Dig Endosc. 2021;12:11–8.

Article  Google Scholar 

Krishnamurthy V, Joseph A, Venkataraman S, Kurian G. Simethicone and N-acetyl cysteine combination as premedication before esophagogastroduodenoscopy: double-blind randomized controlled trial. Endosc Int Open. 2022;10:E585–92.

Article  PubMed  PubMed Central  Google Scholar 

Woo JG, Kim TO, Kim HJ, et al. Determination of the optimal time for premedication with pronase, dimethylpolysiloxane, and sodium bicarbonate for upper gastrointestinal endoscopy. J Clin Gastroenterol. 2013;47:389–92.

Article  CAS  PubMed  Google Scholar 

Comments (0)

No login
gif