The authors acknowledge funding from the US National Institutes of Health (1R15GM126510). The article will be deposited on the NIHMS system/PMC. The authors’ work was independent of the funders. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.