Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018;25(3):486–541.

Article  PubMed  PubMed Central  Google Scholar 

Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 2017;171(2):273–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stockwell BR, Jiang X, Gu W. Emerging mechanisms and disease relevance of ferroptosis. Trends Cell Biol. 2020;30(6):478–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lei G, Zhuang L, Gan B. Targeting ferroptosis as a vulnerability in cancer. Nat Rev Cancer. 2022;22(7):381–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2021. CA Cancer J Clin. 2021;71(1):7–33.

Article  PubMed  Google Scholar 

Hassannia B, Vandenabeele P, Vanden BT. Targeting ferroptosis to iron out cancer. Cancer Cell. 2019;35(6):830–49.

Article  CAS  PubMed  Google Scholar 

Wang H, Lin D, Yu Q, Li Z, Lenahan C, Dong Y, et al. A Promising future of ferroptosis in tumor therapy. Front Cell Dev Biol. 2021;9:629150.

Article  PubMed  PubMed Central  Google Scholar 

The LO. Rethinking traditional Chinese medicines for cancer. Lancet Oncol. 2015;16(15):1439.

Article  Google Scholar 

Zhang R, Pan T, Xiang Y, Zhang M, Xie H, Liang Z, et al. Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis. Bioact Mater. 2022;13:23–36.

Article  PubMed  Google Scholar 

Zhao YY, Yang YQ, Sheng HH, Tang Q, Han L, Wang SM, et al. GPX4 plays a crucial role in Fuzheng Kang’ai decoction-induced non-small cell lung cancer cell ferroptosis. Front Pharmacol. 2022;13:851680.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu G, Wang H, Li X, Huang R, Luo L. Recent progress on targeting ferroptosis for cancer therapy. Biochem Pharmacol. 2021;190:114584.

Article  CAS  PubMed  Google Scholar 

Mei H, Zhao L, Li W, Zheng Z, Tang D, Lu X, et al. Inhibition of ferroptosis protects House Ear Institute-Organ of Corti 1 cells and cochlear hair cells from cisplatin-induced ototoxicity. J Cell Mol Med. 2020;24(20):12065–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reis A, Spickett CM. Chemistry of phospholipid oxidation. Biochem Biophys Acta. 2012;1818(10):2374–87.

Article  CAS  PubMed  Google Scholar 

Forcina GC, Dixon SJ. GPX4 at the crossroads of lipid homeostasis and ferroptosis. Proteomics. 2019;19(18):e1800311.

Article  PubMed  Google Scholar 

Wang Y, Yu L, Ding J, Chen Y. Iron metabolism in cancer. Int J Mol Sci. 2018;20(1):E95.

Article  Google Scholar 

Tabnak P, HajiEsmailPoor Z, Soraneh S. Ferroptosis in lung cancer: from molecular mechanisms to prognostic and therapeutic opportunities. Front Oncol. 2021;11:792827.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mullen PJ, Yu R, Longo J, Archer MC, Penn LZ. The interplay between cell signalling and the mevalonate pathway in cancer. Nat Rev Cancer. 2016;16(11):718–31.

Article  CAS  PubMed  Google Scholar 

Zhu J, Berisa M, Schwörer S, Qin W, Cross JR, Thompson CB. Transsulfuration activity can support cell growth upon extracellular cysteine limitation. Cell Metab. 2019;30(5):865-76.e5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Fan Z, Yang Y, Gu C. Iron metabolism and its contribution to cancer (Review). Int J Oncol. 2019;54(4):1143–54.

CAS  PubMed  Google Scholar 

Mou Y. Ferroptosis, a new form of cell death: opportunities and challenges in cancer. J Hematol Oncol. 2019. https://doi.org/10.1186/s13045-019-0720-y.

Article  PubMed  PubMed Central  Google Scholar 

Khalil S, Holy M, Grado S, Fleming R, Kurita R, Nakamura Y, et al. A specialized pathway for erythroid iron delivery through lysosomal trafficking of transferrin receptor 2. Blood Adv. 2017;1(15):1181–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Z, Chen L, Chen C, Zhou Y, Hu D, Yang J, et al. Targeting ferroptosis in breast cancer. Biomark Res. 2020;8(1):58.

Article  PubMed  PubMed Central  Google Scholar 

Hou W, Xie Y, Song X, Sun X, Lotze MT, Zeh HJ, et al. Autophagy promotes ferroptosis by degradation of ferritin. Autophagy. 2016;12(8):1425–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Wei Z, Pan K, Li J, Chen Q. The function and mechanism of ferroptosis in cancer. Apoptosis. 2020;25(11–12):786–98.

Article  CAS  PubMed  Google Scholar 

Alvarez SW, Possemato R. Leveraging the iron-starvation response to promote ferroptosis. Oncotarget. 2018;9(13):10830–1.

Article  PubMed  PubMed Central  Google Scholar 

Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, et al. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis. Nature. 2017;551(7682):639–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuan Z-H, Liu T, Wang H, Xue L-X, Wang J-J. Fatty acids metabolism: the bridge between ferroptosis and ionizing radiation. Front Cell Dev Biol. 2021;9:675617.

Article  PubMed  PubMed Central  Google Scholar 

Brown CW, Amante JJ, Goel HL, Mercurio AM. The α6β4 integrin promotes resistance to ferroptosis. J Cell Biol. 2017;216(12):4287–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li D, Li Y. The interaction between ferroptosis and lipid metabolism in cancer. Signal Transduct Target Ther. 2020;5(1):108.

Article  PubMed  PubMed Central  Google Scholar 

Li L, Qiu C, Hou M, Wang X, Huang C, Zou J, et al. Ferroptosis in ovarian cancer: a novel therapeutic strategy. Front Oncol. 2021;11:665945.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao N, et al. Ferroptosis: past, present and future. Cell Death Dis. 2020;11(2):88.

Article  PubMed  PubMed Central  Google Scholar 

Yagoda N, von Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, et al. RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature. 2007;447(7146):864–8.

Article  PubMed  PubMed Central  Google Scholar 

Yan H, Bu P. Non-coding RNA in cancer. Essays Biochem. 2021;65(4):625–39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Z, Chen X, Liu N, Shi Y, Liu Y, Ouyang L, et al. A nuclear long non-coding RNA LINC00618 accelerates ferroptosis in a manner dependent upon apoptosis. Mol Ther. 2021;29(1):263–74.

Article  CAS  PubMed  Google Scholar 

Kang R, Kroemer G, Tang D. The tumor suppressor protein p53 and the ferroptosis network. Free Radical Biol Med. 2019;133:162–8.

Article  CAS  Google Scholar 

Ou Y, Wang S-J, Li D, Chu B, Gu W. Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses. Proc Natl Acad Sci USA. 2016;113(44):E6806–12.

Article  CAS  PubMed