aUniversity of Rennes CHU Rennes, Inserm, EHESP, Irset -Institut de Recherche en Santé, Environnement et Travail-UMRS

bDepartment of Internal Medicine and Clinical Immunology, CHU Rennes, Rennes, France

cUniversity of Michigan Scleroderma Program, Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA

Correspondence to Alain Lescoat, Department of Internal Medicine and Clinical Immunology, CHU Rennes, University of Rennes 1, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail), UMR_S 1085, Rennes, France. E-mail: [email protected]