Felipe Sierra1 and Ronald A. Kohanski2 1Hevolution Foundation, Riyadh 13519, Saudi Arabia 2Division of Aging Biology, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20814, USA Correspondence: f.sierrahevolution.com

The conceptualization of the field of geroscience, which began about 10 years ago, marks, together with the publication of “The hallmarks of aging” (see López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Cell 153: 1194–1217, 2013), a significant watershed in the development of aging research. Based on a very simple and commonly accepted premise, namely, that aging biology is at the core the most significant risk factor for all chronic diseases affecting the elderly, geroscience became possible because of earlier significant developments in the field of aging biology. Here we describe the origins of the concept, as well as its current status in the field. The principles of geroscience provide an important new biomedical perspective and have spawned a significantly increased interest in aging biology within the larger biomedical scientific community.