Bae H, Song G (2020) Stigmasterol causes ovarian cancer cell apoptosis by inducing endoplasmic reticulum and mitochondrial dysfunction. Pharmaceutics 12:488

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J et al (2019) DNA methylation biomarkers in stool for early screening of colorectal cancer. J Cancer 10:5264–5271

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dekker E et al (2019) Colorectal cancer. Lancet 394:1467–1480

Article  PubMed  Google Scholar 

Du W et al (2012) Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway. J Cell Mol Med 16:1878–1888

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hao W et al (2015) Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways. Sci Rep 5:10336

Article  CAS  PubMed  PubMed Central  Google Scholar 

He Y et al (2021) Chrysin induces autophagy through the inactivation of the ROS-mediated Akt/mTOR signaling pathway in endometrial cancer. Int J Mol Med. https://doi.org/10.3892/ijmm.2021.5005

Article  PubMed  PubMed Central  Google Scholar 

Jiang F et al (2021) Fangchinoline exerts antitumour activity by suppressing the EGFR-PI3K/AKT signalling pathway in colon adenocarcinoma. Oncol Rep 45:139–150

Article  PubMed  Google Scholar 

Kobayashi Y, Kumamoto K, Okayama H (2021) Downregulation of PAICS due to loss of chromosome 4q is associated with poor survival in stage III colorectal cancer. PLoS ONE 16:e0247169

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lai RK et al (2016) NDUFA4L2 fine-tunes oxidative stress in hepatocellular carcinoma. Clin Cancer Res 22:3105–3117

Article  CAS  PubMed  Google Scholar 

Laursen KB et al (2021) Mitochondrial Ndufa4l2 enhances deposition of lipids and expression of Ca9 in the track model of early clear cell renal cell carcinoma. Front Oncol 11:783856

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X et al (2020) INHBA is a prognostic predictor for patients with colon adenocarcinoma. BMC Cancer 20(1):305

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu L et al (2016) NDUFA4L2 expression predicts poor prognosis in clear cell renal cell carcinoma patients. Ren Fail 38:1199–1205

Article  PubMed  Google Scholar 

Liu Y et al (2021a) NDUFA4L2 in smooth muscle promotes vascular remodeling in hypoxic pulmonary arterial hypertension. J Cell Mol Med 25:1221–1237

Article  CAS  PubMed  Google Scholar 

Liu Z et al (2021b) Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force. FASEB J 35:e22010

Article  CAS  PubMed  Google Scholar 

Meng Q, Shi S (2018) Abrogation of glutathione peroxidase-1 drives EMT and chemoresistance in pancreatic cancer by activating ROS-mediated Akt/GSK3β/Snail signaling. Oncogene 37:5843–5857

Article  CAS  PubMed  Google Scholar 

Meng L et al (2019) Mitochondrial NDUFA4L2 protein promotes the vitality of lung cancer cells by repressing oxidative stress. Thoracic Cancer 10:676–685

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qiu J et al (2019) Hyperoside induces breast cancer cells apoptosis via ROS-mediated NF-κB signaling pathway. Int J Mol Sci 21:131

Article  PubMed  PubMed Central  Google Scholar 

Qureshi-Baig K et al (2020) Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway. Autophagy 16:1436–1452

Article  CAS  PubMed  Google Scholar 

Ruan DY et al (2021) FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis. Oncogene 40:5168–5181

Article  CAS  PubMed  PubMed Central  Google Scholar 

Scatena R (2012) Mitochondria and cancer: a growing role in apoptosis, cancer cell metabolism and dedifferentiation. Adv Exp Med Biol 942:287–308

Article  CAS  PubMed  Google Scholar 

Song X et al (2017) Dioscin induces gallbladder cancer apoptosis by inhibiting ROS-mediated PI3K/AKT signalling. Int J Biol Sci 13:782–793

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tam SY, Wu VWC, Law HKW (2020) Hypoxia-induced epithelial-mesenchymal transition in cancers: HIF-1α and beyond. Front Oncol 10:486

Article  PubMed  PubMed Central  Google Scholar 

Tang Y-A et al (2018) Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer. Proc Natl Acad Sci 115:E5990–E5999

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang L et al (2022) PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages. J Exp Clin Cancer Res 41:303

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wilson WR, Hay MP (2011) Targeting hypoxia in cancer therapy. Nat Rev Cancer 11:393–410

Article  CAS  PubMed  Google Scholar 

Xing Y et al (2019) ZNF692 promotes colon adenocarcinoma cell growth and metastasis by activating the PI3K/AKT pathway. Int J Oncol 54:1691–1703

CAS  PubMed  PubMed Central  Google Scholar 

Xu WN et al (2020) NDUFA4L2 regulated by HIF-1α promotes metastasis and epithelial-mesenchymal transition of osteosarcoma cells through inhibiting ROS production. Front Cell Dev Biol 8:515051

Article  PubMed  PubMed Central  Google Scholar 

Yuan Y et al (2021) NDUFA4L2 promotes trastuzumab resistance in HER2-positive breast cancer. Ther Adv Med Oncol 13:17588359211027836

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang WL et al (2020) Extracellular vesicle long non-coding RNA-mediated crosstalk in the tumor microenvironment: tiny molecules, huge roles. Cancer Sci 111:2726–2735

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang P et al (2020) Metformin enhances the sensitivity of colorectal cancer cells to cisplatin through ROS-mediated PI3K/Akt signaling pathway. Gene 745:144623

Article  CAS  PubMed  Google Scholar 

Zhao B et al (2020) Comprehensive analysis reveals a four-gene signature in colorectal cancer. Transl Cancer Res 9:1395–1405

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou F, Wang L (2021) RecQ-like helicase 4 (RECQL4) exacerbates resistance to oxaliplatin in colon adenocarcinoma via activation of the PI3K/AKT signaling pathway. Bioengineered 12:5859–5869

Article  CAS  PubMed  PubMed Central  Google Scholar