1000 Genomes Project Consortium, Auton A., Brooks L. D., Durbin R. M., Garrison E. P., Kang H. M. et al. 2015 A global reference for human genetic variation. Nature 526, 68–74.

Article  Google Scholar 

Adzhubei I., Jordan D. M. and Sunyaev S. R. 2013 Predicting functional effect of human missense mutations using PolyPhen-2. Curr. Protoc. Hum. Genet. 76(1), 7–20.

Google Scholar 

Andaya L. Y. 2001 The search for the “origins” of Melayu. J. Southeast Asian Stud. 32, 315–330.

Article  Google Scholar 

Ang G. Y., Yu C. Y., Subramaniam V., Khalid M. I. H., Aziz T. A. T., James R. J. et al. 2016 Detection of CYP2C19 genetic variants in Malaysian Orang Asli from massively parallel sequencing data. PLoS One 11, e0164169.

Article  PubMed  PubMed Central  Google Scholar 

Barker G., Barton H., Beavitt P., Bird M., Daly P., Doherty C. et al. 2002 Prehistoric foragers and farmers in South-East Asia: renewed investigations at Niah Cave, Sarawak. Proc. Prehist. Soc. 68, 147–164.

Article  Google Scholar 

Bellwood P. S. 1993 Cultural and biological differentiation in Peninsular Malaysia: the last 10,000 years. Asian Perspect. 32, 1.

Google Scholar 

Chen D.-P., Tseng C.-P., Wang W.-T., Peng C.-T., Tsao K.-C. and Wu T.-L. 2004 Two prevalent h alleles in para-Bombay haplotypes among 250,000 Taiwanese. Ann. Clin. Lab. Sci. 34, 314–318.

CAS  PubMed  Google Scholar 

Choi Y. and Chan A. P. 2015 PROVEAN web server: a tool to predict the functional effect of amino acid substitutions and indels. Bioinformatics 31, 2745–2747.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Daniels G. 2013 Human blood groups, John Wiley, Hoboken.

Book  Google Scholar 

Darwina N. and Wan Puteh S. E. 2012 Burden of non-communicable diseases among the Orang Asli community and patient satisfaction on non-communicable diseases management at public health facilities. In BMC public health vol. 12.

Davydov E. V., Goode D. L., Sirota M., Cooper G. M., Sidow A. and Batzoglou S. 2010 Identifying a high fraction of the human genome to be under selective constraint using GERP++. PLoS Comput. Biol. 6, e1001025.

Article  PubMed  PubMed Central  Google Scholar 

Deng L., Hoh B. P., Lu D., Fu R., Phipps M. E., Li S. et al. 2014 The population genomic landscape of human genetic structure, admixture history and local adaptation in Peninsular Malaysia. Hum. Genet. 133, 1169–1185.

Article  PubMed  Google Scholar 

Deng L., Hoh B.-P., Lu D., Saw W.-Y., Twee-Hee Ong R., Kasturiratne A. et al. 2015 Dissecting the genetic structure and admixture of four geographical Malay populations. Sci. Rep. 5, 14375.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Diamond J. M. 2000 Taiwan’s gift to the world. Nature 403, 709–710.

Article  CAS  PubMed  Google Scholar 

Giollo M., Minervini G., Scalzotto M., Leonardi E., Ferrari C. and Tosatto S. C. E. 2015 BOOGIE: predicting blood groups from high throughput sequencing data. PLoS One 10, e0124579.

Article  PubMed  PubMed Central  Google Scholar 

Gnad F., Baucom A., Mukhyala K., Manning G. and Zhang Z. 2013 Assessment of computational methods for predicting the effects of missense mutations in human cancers. BMC Genom. 14, S7.

Article  Google Scholar 

Hill C., Soares P., Mormina M., Macaulay V., Meehan W., Blackburn J. et al. 2006 Phylogeography and ethnogenesis of aboriginal Southeast Asians. Mol. Biol. Evol. 23, 2480–2491.

Article  CAS  PubMed  Google Scholar 

Hue-Roye K., Lomas-Francis C., Coghlan G., Zelinski T. and Reid M. E. 2013a The JR blood group system (ISBT 032): molecular characterization of three new null alleles. Transfusion 53, 1575–1579.

Article  PubMed  Google Scholar 

Hue-Roye K., Zelinski T., Cobaugh A., Lomas-Francis C., Miyazaki T., Tani Y. et al. 2013b The JR blood group system: identification of alleles that alter expression. Transfusion 53, 2710–2714.

Article  CAS  PubMed  Google Scholar 

HUGO Pan-Asian SNP Consortium, Abdulla M. A., Ahmed I., Assawamakin A., Bhak J., Brahmachari S. K. et al. 2009 Mapping human genetic diversity in Asia. Science 326, 1541–1545.

Article  Google Scholar 

Ichinose A., Bottenus R. E. and Davie E. W. 1990 Structure of transglutaminases. J. Biol. Chem. 265, 13411–13414.

Article  CAS  PubMed  Google Scholar 

Karczewski K. J., Francioli L. C., Tiao G., Cummings B. B., Alföldi J., Wang Q. et al. 2020 The mutational constraint spectrum quantified from variation in 141,456 humans. Nature 581, 434–443.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim K.-A., Joo H.-J. and Park J.-Y. 2010 ABCG2 polymorphisms, 34G>A and 421C>A in a Korean population: analysis and a comprehensive comparison with other populations. In J. Clin. Pharm. Ther. 35, 705–712.

Article  Google Scholar 

Kirkitadze M. D. and Barlow P. N. 2001 Structure and flexibility of the multiple domain proteins that regulate complement activation. Immunol. Rev. 180, 146–161.

Article  CAS  PubMed  Google Scholar 

Koh D. X. R., Raja Sabudin R. Z. A., Mohd Yusoff M., Hussin N. H., Ahmad R., Othman A. et al. 2017 Molecular characterisation of α- and β-thalassaemia among Indigenous Senoi Orang Asli communities in Peninsular Malaysia. Ann. Hum. Genet. 81, 205–212.

Article  CAS  PubMed  Google Scholar 

Lane W. J., Westhoff C. M., Uy J. M., Aguad M., Smeland-Wagman R., Kaufman R. M. et al. 2016 Comprehensive red blood cell and platelet antigen prediction from whole genome sequencing: proof of principle. Transfusion 56, 743–754.

Article  CAS  PubMed  Google Scholar 

Lek M., Karczewski K. J., Minikel E. V., Samocha K. E., Banks E., Fennell T. et al. 2016 Analysis of protein-coding genetic variation in 60,706 humans. Nature 536, 285–291.

Article  CAS  PubMed  PubMed Central  Google Scholar 

MacArthur J. A. L., Morales J., Tully R. E., Astashyn A., Gil L., Bruford E. A. et al. 2014 Locus reference genomic: reference sequences for the reporting of clinically relevant sequence variants. Nucleic Acids Res. 42, D873–D878.

Article  CAS  PubMed  Google Scholar 

Masumoto A., Masuyama H., Sumida Y., Segawa T. and Hiramatsu Y. 2010 Successful management of anti-Jra alloimmunization in pregnancy: a case report. Gynecol. Obstet. Invest. 69, 81–83.

Article  PubMed  Google Scholar 

Matzhold E. M., Helmberg W., Wagner T., Drexler C., Ulrich S., Winkler A. et al. 2009 Identification of 14 new alleles at the fucosyltransferase 1, 2, and 3 loci in Styrian blood donors, Austria. Transfusion 49, 2097–2108.

Article  CAS  PubMed  Google Scholar 

Ng P. C. and Henikoff S. 2003 SIFT: predicting amino acid changes that affect protein function. Nucleic Acid Res. 31, 3812–3814.

Article  CAS  PubMed  PubMed Central  Google Scholar 

NurWaliyuddin H. Z. A., Norazmi M. N., Edinur H. A., Chambers G. K., Panneerchelvam S. and Zafarina Z. 2015 Ancient genetic signatures of Orang Asli revealed by killer Immunoglobulin-like receptor gene polymorphisms. PLoS One 10, e0141536.

Article  PubMed  PubMed Central  Google Scholar 

Ohto H. and Wada I. 2019 Variations of three single nucleotide polymorphisms in ABCG2 modify Jra expression. Int. J. Blood Transfus. Immunohematol. 9, 1.

Article  Google Scholar 

Pandey H., Das S. S. and Chaudhary R. 2014 Red cell alloimmunization in transfused patients: a silent epidemic revisited. Asian J. Transfus. Sci. 8, 75–77.

Article  PubMed  PubMed Central  Google Scholar 

Pollard K. S., Hubisz M. J., Rosenbloom K. R. and Siepel A. 2010 Detection of nonneutral substitution rates on mammalian phylogenies. Genome Res. 20, 110–121.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M. A. R., Bender D. et al. 2007 PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559–575.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rahim M. A. F. A., Rahim M. A. F., Munajat M. B., Wahid W., Dian N. D., Rakna M. I. M. et al. 2021 Anaemia prevalence, severity and associated risk factors among indigenous Temiar Orang Asli community in Kelantan, Peninsular Malaysia. Preprint https://doi.org/10.21203/rs.3.rs-709980/v1.

Reid M. E., Hue-Roye K., Huang A., Velliquette R. W., Tani Y., Westhoff C. M. et al. 2014 Alleles of the LAN blood group system: molecular and serologic investigations. Transfusion 54, 398–404.

CAS  PubMed  Google Scholar 

Rentzsch P., Witten D., Cooper G. M., Shendure J. and Kircher M. 2019 CADD: predicting the deleteriousness of variants throughout the human genome. Nucleic Acids Res. 47, D886–D894.

Article  CAS  PubMed  Google Scholar 

Rieneck K., Bak M., Jønson L., Clausen F. B., Krog G. R., Tommerup N. et al. 2013 Next-generation sequencing: proof of concept for antenatal prediction of the fetal Kell blood group phenotype from cell-free fetal DNA in maternal plasma. Transfusion 53, 2892–2898.

CAS  PubMed  Google Scholar 

Ring I. 2003 The health status of indigenous peoples and others. Br. Med. J. 327, 404–405.

Article  Google Scholar 

Rophina M., Pandhare K., Jadhao S., Nagaraj S. H. and Scaria V. 2022 BGvar: a comprehensive resource for blood group immunogenetics. Transfus. Med. 32, 229–236.

Article