Document Type : Original Article

Authors

1 Neonatologist, Associate professor, Neonatal and Children’s Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran

2 Pathologist,Department of Pathology, School of Medicine 5th Azar Hospital, Sayyad Shirazi Hospital Golestan University of Medical Sciences

3 pediatrician, neonatal and children health research center,Golestan university of medical sciences, Gorgan, Iran

4 Pediatrician, neonatal and children health research center, Golestan university of medical sciences, Gorgan ,Iran

5 Department of Nephrology, Clinical Research Development Unit, Sayad Shirazi Hospital, Golestan University of Medical Sciences

10.22038/ijn.2023.70896.2385

Abstract

Introduction:

Drugs cause approximately 20%-40% of acute kidney Injuries (AKI). Amikacin (AMK) is one of the common medications used as empiric therapy for severe infections such as sepsis in neonates. One of the newly recommended biomarkers in AKI is Kidney Injury Molecule-1 (KIM-1). In this study, we evaluated the use of KIM-1 for diagnosing tubular injury in neonates treated with AK in the Neonatal intensive care unit (NICU) of our educational hospital, Gorgan.

Methods:

This cross-sectional descriptive study was conducted at the NICU of the two educational hospitals of Golestan University of Medical Sciences, Gorgan. There were two groups of patients: neonates treated with Amikacin plus Ampicillin (group A; N=45), and neonates treated with Ampicillin plus Cefotaxime (group B; N=45). Demographic data were collected. Blood and urine samples were collected in both groups. The urinary secretion of KIM-1 was determined using an ELISA kit.

Results:

The total number of patients in both groups was 45, 26(57.8%) were male and 19(42.2%) were female. The mean age was 5.25±1.47 days in the Amikacin group and 5.15±1.5 days in the other group. None of our patients had acute kidney injury (AKI). There was no difference between Leukocyte count and platelets on the first and seventh day. There was a significant difference between K, Na, urine SG, CRP, Cr, and BUN on the seventh day compared to the first day. The difference between urinary levels of KIM-1 in the two groups was not statistically significant.

Conclusions:

We have not found a significant relationship between urinary KIM-1 and acute kidney injury in our patients.

Keywords:

Acute Kidney Injuries, Neonate, Neonatal Intensive Care Unit

Keywords