Document Type : Original Article

Authors

1 Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Science

2 Maternal-Fetal and Neonatal Health Research Center, Vali-e Asr Hospital, Imam Khomeini hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

3 Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

10.22038/ijn.2023.70013.2357

Abstract

Background: Magnesium (Mg), a vital element, has a crucial role in the human body. Respiratory distress syndrome (RDS) is one of the most common problems in preterm neonates. In this study, we aim to investigate the role of serum Mg level as a prognostic factor for neonates with RDS.

Method: This case-control study was performed in Vali-e-Asr Hospital for two years in Tehran, Iran. One hundred preterm infants admitted to NICU enrolled in this study (50 cases,50 controls). Demographic data, serum magnesium level, therapeutic interventions, and neonatal outcomes were investigated and analyzed by SPSS software; P-value less than 0.05 was considered significant.

Result: Of 100 neonates, 52% were male. The mean gestational age and birth weights were 33.4 2.4 weeks and 2062 72 grams, respectively.

The mean serum magnesium level in neonates with RDS was 2.020.57 mg/dl, while it was 2.350.67 mg/dl among neonates in the control group (P-value=0.001). In this study, the odd ratio of 2.38 suggested a correlation between the lower level of serum Mg and RDS.

Conclusion: The serum level of Mg among neonates with RDS was significantly lower, but the lower level of Mg was not associated with adverse outcomes in neonates.

Keywords