Joint fluid interleukin-6 combined with the neutral polymorphonuclear leukocyte ratio (PMN%) as a diagnostic index for chronic periprosthesis infection after arthroplasty

Qin L, Li F, Gong X, Wang J, Huang W, Hu N (2020) Combined measurement of D-dimer and C-reactive protein levels: highly accurate for diagnosing chronic periprosthetic joint infection. J Arthroplasty 35(1):229–234

Article  PubMed  Google Scholar 

Cai YQ, Fang XY, Huang CY, Li ZM, Huang ZD, Zhang CF, Li WB, Zhang ZZ, Guan ZP, Zhang WM (2021) Destination joint spacers: a similar infection-relief rate but higher complication rate compared with two-stage revision. Orthop Surg 13(3):884–891

Article  PubMed  PubMed Central  Google Scholar 

Goswami K, Parvizi J, Maxwell Courtney P (2018) Current recommendations for the diagnosis of acute and chronic PJI for hip and knee-cell counts, alpha-defensin, leukocyte esterase next-generation sequencing. Curr Rev Musculoskelet Med 11(3):428–438

Article  PubMed  PubMed Central  Google Scholar 

Kheir MM, Tan TL, Shohat N, Foltz C, Parvizi J (2018) Routine diagnostic tests for periprosthetic joint infection demonstrate a high false-negative rate and are influenced by the infecting organism. J Bone Joint Surg Am 100(23):2057–2065

Article  PubMed  Google Scholar 

Bozic KJ, Kurtz SM, Lau E, Ong K, Chiu V, Vail TP, Rubash HE, Berry DJ (2010) The epidemiology of revision total knee arthroplasty in the United States. Clin Orthop Relat Res 468(1):45–51

Article  PubMed  Google Scholar 

Gwam CU, Mistry JB, Mohamed NS, Thomas M, Bigart KC, Mont MA, Delanois RE (2017) Current epidemiology of revision total hip arthroplasty in the United States: national inpatient sample 2009 to 2013. J Arthroplasty 32(7):2088–2092

Article  PubMed  Google Scholar 

Qin L, Li X, Wang J, Gong X, Hu N, Huang W (2020) Improved diagnosis of chronic hip and knee prosthetic joint infection using combined serum and synovial IL-6 tests. Bone Joint Res 9(9):587–592

Article  PubMed  PubMed Central  Google Scholar 

Marazzi MG, Randelli F, Brioschi M, Drago L, Romanò CL, Banfi G, Massaccesi L, Crapanzano C, Morelli F, Corsi Romanelli MM, Galliera E (2018) Presepsin: a potential biomarker of PJI? A comparative analysis with known and new infection biomarkers. Int J Immunopathol Pharmacol 31:394632017749356

Article  PubMed  Google Scholar 

Galliera E, Drago L, Vassena C, Romanò C, Gioia Marazzi M, Salcito L, Corsi Romanelli MM (2014) Toll-like receptor 2 in serum: a potential diagnostic marker of prosthetic joint infection? J Clin Microbiol 52(2):620–623

Article  PubMed  PubMed Central  Google Scholar 

Raby AC, Holst B, Le Bouder E, Diaz C, Ferran E, Conraux L, Guillemot JC, Coles B, Kift-Morgan A, Colmont CS, Szakmany T, Ferrara P, Hall JE, Topley N, Labéta MO (2013) Targeting the TLR co-receptor CD14 with TLR2-derived peptides modulates immune responses to pathogens. Sci Transl Med 5(185):185

Article  Google Scholar 

Shahi A, Parvizi J (2017) The role of biomarkers in the diagnosis of periprosthetic joint infection. EFORT Open Rev 1(7):275–278

Article  PubMed  Google Scholar 

Wetters NG, Berend KR, Lombardi AV, Morris MJ, Tucker TL, Della Valle CJ (2012) Leukocyte esterase reagent strips for the rapid diagnosis of periprosthetic joint infection. J Arthroplasty 27(8 Suppl):8–11

Article  PubMed  Google Scholar 

Mihara M, Hashizume M, Yoshida H, Suzuki M, Shiina M (2012) IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Clin Sci 122(4):143–159

Article  CAS  Google Scholar 

Randau TM, Friedrich MJ, Wimmer MD, Reichert B, Kuberra D, Stoffel-Wagner B, Limmer A, Wirtz DC, Gravius S (2014) Interleukin-6 in serum and in synovial fluid enhances the differentiation between periprosthetic joint infection and aseptic loosening. PLoS ONE 9(2):e89045

Article  PubMed  PubMed Central  Google Scholar 

Huang S, Thomsson KA, Jin C, Ryberg H, Das N, Struglics A, Rolfson O, Björkman LI, Eisler T, Schmidt TA, Jay GD, Krawetz R, Karlsson NG (2022) Truncated lubricin glycans in osteoarthritis stimulate the synoviocyte secretion of VEGFA, IL-8, and MIP-1α: interplay between O-linked glycosylation and inflammatory cytokines. Front Mol Biosci 9:942406

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parvizi J, Gehrke T (2014) Definition of periprosthetic joint infection. J Arthroplasty 29(7):1331

Article  PubMed  Google Scholar 

Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM, Rao N, Hanssen A, Wilson WR (2013) Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 56(1):e1–e25

Sanzén L, Sundberg M (1997) Periprosthetic low-grade hip infections. Erythrocyte sedimentation rate and C-reactive protein in 23 cases. Acta Orthop Scand 68(5):461–5

Article  PubMed  Google Scholar 

Hackett DJ, Rothenberg AC, Chen AF, Gutowski C, Jaekel D, Tomek IM, Parsley BS, Ducheyne P, Manner PA (2015) The economic significance of orthopaedic infections. J Am Acad Orthop Surg 23(Suppl):S1-7

Article  PubMed  Google Scholar 

Bozic KJ, Kurtz SM, Lau E, Ong K, Vail TP, Berry DJ (2009) The epidemiology of revision total hip arthroplasty in the United States. J Bone Joint Surg Am 91(1):128–133

Article  PubMed  Google Scholar 

Bergin PF, Doppelt JD, Hamilton WG, Mirick GE, Jones AE, Sritulanondha S, Helm JM, Tuan RS (2010) Detection of periprosthetic infections with use of ribosomal RNA-based polymerase chain reaction. J Bone Joint Surg Am 92(3):654–663

Article  PubMed  PubMed Central  Google Scholar 

Haddad FS (2018) Next generation sequencing: is this the moment? Bone Joint J 100(2):125–126

Article  PubMed  Google Scholar 

Zhao J, Wang J, Liu Y, Han XX, Xu B, Ozaki Y, Zhao B (2022) Detection of prostate cancer biomarkers via a SERS-based aptasensor. Biosens Bioelectron 216:114660

Article  CAS  PubMed  Google Scholar 

Zhang L, Huang Y, Lin Y, Zhang A, Zou R, Xu H, Wang S (2022) Prognostic significance of CD56 expression in patients with multiple myeloma: a meta-analysis. Hematology 27(1):122–131

Article  CAS  PubMed  Google Scholar 

Xie K, Dai K, Qu X, Yan M (2017) Serum and synovial fluid interleukin-6 for the diagnosis of periprosthetic joint infection. Sci Rep 7(1):1496

Article  PubMed  PubMed Central  Google Scholar 

Helfgott DC, Tatter SB, Santhanam U, Clarick RH, Bhardwaj N, May LT, Sehgal PB (1989) Multiple forms of IFN-beta 2/IL-6 in serum and body fluids during acute bacterial infection. J Immunol 142(3):948–953

Article  CAS  PubMed  Google Scholar 

Póvoa P (2002) C-reactive protein: a valuable marker of sepsis. Intensive Care Med 28(3):235–243

Article  PubMed  Google Scholar 

Kraus RF, Gruber MA (2021) Neutrophils—from bone marrow to first-line defense of the innate immune system. Front Immunol 12:767175

Grzelecki D, Walczak P, Szostek M, Grajek A, Rak S, Kowalczewski J (2021) Blood and synovial fluid calprotectin as biomarkers to diagnose chronic hip and knee periprosthetic joint infections. Bone Joint J 103(1):46–55

Article  PubMed  Google Scholar 

Di Cesare PE, Chang E, Preston CF, Liu CJ (2005) Serum interleukin-6 as a marker of periprosthetic infection following total hip and knee arthroplasty. J Bone Joint Surg Am 87(9):1921–1927

Article  PubMed  Google Scholar 

Gallo J, Svoboda M, Zapletalova J, Proskova J, Juranova J (2018) Serum IL-6 in combination with synovial IL-6/CRP shows excellent diagnostic power to detect hip and knee prosthetic joint infection. PLoS ONE 13(6):e0199226

Article  PubMed  PubMed Central  Google Scholar 

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