Advances in Pharmacology and Pharmacy Vol. 11(4), pp. 279 - 288
DOI: 10.13189/app.2023.110405
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Ream Nayal 1,*, Angela Espir 1, Mohammad Y. Abajy 2
1 Department of Pharmacognosy, Faculty of Pharmacy, Aleppo University, Syria
2 Department of Biochemistry and Microbiology, Faculty of Pharmacy, Aleppo University, Syria

ABSTRACT

Obesity is a global issue and can predispose to metabolic diseases such as, type 2 diabetes, atherosclerosis and cardiovascular disease. One of the therapeutic strategies in managing obesity is the inhibition of pancreatic lipase. In this study, the inhibitory activity of different polar extracts of C. azarolus and A. syriacum on porcine pancreatic lipase was evaluated in vitro. Results showed that the best inhibitory activity was for C. azarolus hydroethanolic extract (IC50 =0.204 mg/ml). Therefore, the antiobesity effect of this extract was studied by using wistar rats that had been obese due to a high-fat diet. Oral treatment with 400mg/kg (body weight) of this extract for 6 weeks resulted in body weight reduction similar (p>0.05) to orlistat group (the positive control). Moreover, the ethanol extract decreased significantly the visceral adipose, adiposity index and liver weight in treated group compared to the high-fat control group (p

KEYWORDS
Crataegus azarolus, Acer syriacum, Lipase, Obesity, High-Fat-Diet, Adiposity Index

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Ream Nayal , Angela Espir , Mohammad Y. Abajy , "Investigating the Anti-Obesity Potential of Crataegus azarolus and Acer syriacum," Advances in Pharmacology and Pharmacy, Vol. 11, No. 4, pp. 279 - 288, 2023. DOI: 10.13189/app.2023.110405.

(b). APA Format:
Ream Nayal , Angela Espir , Mohammad Y. Abajy (2023). Investigating the Anti-Obesity Potential of Crataegus azarolus and Acer syriacum. Advances in Pharmacology and Pharmacy, 11(4), 279 - 288. DOI: 10.13189/app.2023.110405.