1 Department of Microbiology and Immunology, Louisiana State University Health – Shreveport, Shreveport, LA 71130.

2 Department of Molecular and Cellular Physiology, Louisiana State University Health – Shreveport, Shreveport, LA 71130.

3 Innovative North Louisiana Experimental Therapeutics program (INLET), Feist-Weiller Cancer Center, Louisiana State University Health – Shreveport, Shreveport, LA 71130.

# Equal contribution.

Keywords: Legionella pneumophila, macrophage, intracellular replication, cholesterol, niche homeostasis.

Abbreviations:

BMDM – bone marrow-derived macrophage,

ER – endoplasmic reticulum,

hpi – hours post infection,

LCV – Legionella-containing vacuole,

LDL – low-density lipoprotein,

Lp – Legionella pneumophila,

MFI – mean fluorescens intensity,

MOI – multiplicity of infection,

MTOR – mechanistic target of rapamycin,

T2SS- type II secretion system.
Received originally: 20/08/2022 Received in revised form: 28/11/2022
Accepted: 30/11/2022 Published: 06/12/2022

Correspondence:
Stanimir S. Ivanov, Department of Microbiology and Immunology, Louisiana State University Health - Shreveport, Shreveport, LA 71130; stanimir.ivanov@lsuhs.edu

Conflict of interest statement: The authors declare that no competing interests exist.
Please cite this article as: Edna Ondari, Ashley Wilkins, Brian Latimer, Ana-Maria Dragoi and Stanimir S. Ivanov (2022). Cellular cholesterol licenses Legionella pneumophila intracellular replication in mac-rophages. Microbial Cell 10(1): 1-17. doi: 10.15698/mic2023.01.789