Deciphering the potentiality of Andrographolide derivatives against : in vitro analysis and mechanistic insights

Adnan M et al (2020) Effect of Adiantum philippense Extract on Biofilm Formation, Adhesion With Its Antibacterial Activities Against Foodborne Pathogens, and Characterization of Bioactive Metabolites: An in vitro-in silico Approach. Front Microbiol 11:823. https://doi.org/10.3389/fmicb.2020.00823

Article  PubMed  PubMed Central  Google Scholar 

Ahmed SK et al (2024) Antimicrobial resistance: Impacts, challenges, and future prospects. J Med Surg Public Health 2:100081. https://doi.org/10.1016/j.glmedi.2024.100081

Article  Google Scholar 

Aktekin MB, Oksuz Z, Turkmenoglu B, Istifli ES, Kuzucu M, Algul O (2024) Synthesis and evaluation of di-heterocyclic benzazole compounds as potential antibacterial and anti-biofilm agents against Staphylococcus aureus. Chem Biol Drug Des 104(2):e14601. https://doi.org/10.1111/cbdd.14601

Article  CAS  PubMed  Google Scholar 

Alharbi MS et al (2025) Multidrug-resistant Pseudomonas aeruginosa: Pathogenesis, resistance mechanisms, and novel therapeutic strategies. Virulence 16(1):2580160. https://doi.org/10.1080/21505594.2025.2580160

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aslam B et al (2024) AMR and Sustainable Development Goals: at a crossroads. Global Health 20(1):73. https://doi.org/10.1186/s12992-024-01046-8

Article  PubMed  PubMed Central  Google Scholar 

Banerjee S, Vishakha K, Das S, Sangma PD, Mondal S, Ganguli A (2022) Oxidative stress, DNA, and membranes targets as modes of antibacterial and antibiofilm activity of facile synthesized biocompatible keratin-copper nanoparticles against multidrug resistant uro-pathogens. World J Microbiol Biotechnol 38(2):20. https://doi.org/10.1007/s11274-021-03187-z

Article  CAS  PubMed  Google Scholar 

Bassey K, Mamabolo P, Cosa S (2021) An Andrographolide from Helichrysum caespitium (DC.) Sond. Ex Harv., (Asteraceae) and Its Antimicrobial, Antiquorum Sensing, and Antibiofilm Potentials. Biology 10(12):1224

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhushan A et al (2026) Design and synthesis of novel derivatives of bioactive sesquiterpenes Dehydrocostus lactone and Costunolide and their evaluation as leishmanicidal agents with an improved safety profile. Bioorg Chem 168:109290. https://doi.org/10.1016/j.bioorg.2025.109290

Article  CAS  PubMed  Google Scholar 

Calzetta L, Page C, Matera MG, Cazzola M, Rogliani P (2024) Drug-Drug Interactions and Synergy: From Pharmacological Models to Clinical Application. Pharmacol Rev 76(6):1159–1220. https://doi.org/10.1124/pharmrev.124.000951

Article  CAS  PubMed  Google Scholar 

Chatupheeraphat C, Peamchai J, Luk-In S, Eiamphungporn W (2023) Synergistic effect and antibiofilm activity of the antimicrobial peptide K11 with conventional antibiotics against multidrug-resistant and extensively drug-resistant Klebsiella pneumoniae. Front Cell Infect Microbiol 13:1153868

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Q et al (2012) Pharmacokinetics and tolerance of dehydroandrographolide succinate injection after intravenous administration in healthy Chinese volunteers. Acta Pharmacol Sin 33(10):1332–1336. https://doi.org/10.1038/aps.2012.79

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choudhary S et al (2026) Design, synthesis and biological evaluation of trihydoxy-14-deoxy-11,12-didehydroandrographolide (TDDA) derivatives as TNF-α and IL-6 expression inhibitor. J Mol Str 1350:144054. https://doi.org/10.1016/j.molstruc.2025.144054

Article  CAS  Google Scholar 

Collaborators AR (2022) Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 399(10325):629–655. https://doi.org/10.1016/s0140-6736(21)02724-0

Article  CAS  Google Scholar 

Collaborators GAR (2024) Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050. Lancet 404(10459):1199–1226. https://doi.org/10.1016/s0140-6736(24)01867-1

Article  CAS  Google Scholar 

Cong W et al (2023) Prevalence of antibiotic prescribing in COVID-19 patients in China and other low- and middle-income countries during the pandemic (December 2019-March 2021): a systematic review and meta-analysis. J Antimicrob Chemother 78(12):2787–2794. https://doi.org/10.1093/jac/dkad302

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cooke E, Rendi-Wagner P (2025) Rising antimicrobial resistance in Europe: EMA and ECDC outline urgent actions to achieve EU targets. Lancet Reg Health Eur 59:101539. https://doi.org/10.1016/j.lanepe.2025.101539

Article  PubMed  PubMed Central  Google Scholar 

Coyne AJK et al (2024) Exploring synergistic and antagonistic interactions in phage-antibiotic combinations against ESKAPE pathogens. Microbiol Spectr 12(10):e00427–e00424. https://doi.org/10.1128/spectrum.00427-24

Article  CAS  Google Scholar 

Crone S et al (2020) The environmental occurrence of Pseudomonas aeruginosa. Apmis 128(3):220–231. https://doi.org/10.1111/apm.13010

Article  CAS  PubMed  Google Scholar 

Dafur GS, Harun A, Kub TNT, Bakar RA, Harun A (2024a) A Systematic Review on the Antimicrobial Activity of Andrographolide. J Microbiol Biotechnol 35:e2408028. https://doi.org/10.4014/jmb.2408.08028

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Araújo JM et al (2025) Therapeutic advances in the fight against microbial resistance: innovative strategies and future challenges. Folia Microbiol. https://doi.org/10.1007/s12223-025-01338-5

Article  Google Scholar 

Elfadadny A et al (2024) Antimicrobial resistance of Pseudomonas aeruginosa: navigating clinical impacts, current resistance trends, and innovations in breaking therapies. Front Microbiol 15:1374466. https://doi.org/10.3389/fmicb.2024.1374466

Article  CAS  PubMed  PubMed Central  Google Scholar 

Govindarajan G et al (2021) Susceptibility pattern of methicillin resistance Staphylococcus aureus (MRSA) by flow cytometry analysis and characterization of novel lead drug molecule from Streptomyces species. J Infect Public Health 14(12):1831–1841. https://doi.org/10.1016/j.jiph.2021.11.001

Article  PubMed  Google Scholar 

Haidar A et al (2024) Biofilm formation and antibiotic resistance in Pseudomonas aeruginosa. Microbe 3:100078. https://doi.org/10.1016/j.microb.2024.100078

Article  Google Scholar 

He L et al (2024) Study of andrographolide bioactivity against Pseudomonas aeruginosa based on computational methodology and biochemical analysis. Front Chem 12:1388545. https://doi.org/10.3389/fchem.2024.1388545

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jamwal V, Palmo T, Singh K (2024) Understanding the mechanisms of antimicrobial resistance and potential therapeutic approaches against the Gram-negative pathogen Acinetobacter baumannii. RSC Med Chem 15(12):3925–3949

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jamwal V et al (2026) Deciphering mechanistic and therapeutic insight of pyrazolopyrimidines into MRSA suppression: comprehensive in vitro and in vivo study. Bioorg Chem 172:109596. https://doi.org/10.1016/j.bioorg.2026.109596

Article  CAS  PubMed  Google Scholar 

Jiang X et al (2009) Synthesis and evaluation of antibacterial activities of andrographolide analogues. Eur J Med Chem 44(7):2936–2943. https://doi.org/10.1016/j.ejmech.2008.12.014

Article  CAS  PubMed  Google Scholar 

Kar A, Mukherjee SK, Barik S, Hossain ST (2024) Antimicrobial Activity of Trigonelline Hydrochloride Against Pseudomonas aeruginosa and Its Quorum-Sensing Regulated Molecular Mechanisms on Biofilm Formation and Virulence. ACS Infect Dis 10(2):746–762. https://doi.org/10.1021/acsinfecdis.3c00617

Article  CAS  PubMed  Google Scholar 

Kaur P, Kumar A, Palmo T, Singh K, Tyagi V (2025) Electrochemical N-sulfonylation of in situ generated indole-based hydrazones and antimicrobial evaluation. Org Biomol Chem 23(39):8948–8960. https://doi.org/10.1039/D5OB01107H

Comments (0)

No login
gif