Fig. 1. Endoscopic features suggestive of deep invasion: (A) irregular surface; (B) submucosal tumor-like elevation; (C) nodule in the depressed area; (D) non-extension sign; (E) marked redness; (F) large nodule; (G) deep depression; (H) thickened folds; (I) fusion of folds; (J) depression or thinning; and (K) disruption of the third layer on endoscopic ultrasonography.

Fig. 2. The receiver operating characteristic (ROC) curve based on the diagnostic score showed an area under the ROC curve of 0.891. Using a cutoff value of 3 points, the sensitivity, specificity, and accuracy for predicting pT2-MP were 91.3%, 80.8%, and 82.2%, respectively. AUC, area under the curve; EUS, endoscopic ultrasonography; SMT, submucosal tumor.