Ragel BT, Jensen RL, Couldwell WT (2007) Inflammatory response and meningioma tumorigenesis and the effect of cyclooxygenase-2 inhibitors. Neurosurg Focus 23(4):E7. https://doi.org/10.3171/foc-07/10/e7
WHO Classification of Tumours Editorial Board (2021) World health organization classification of tumours of the central nervous system, 5th edn. International Agency for Research on Cancer, Lyon
Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D et al (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol 23(8):1231–51. https://doi.org/10.1093/neuonc/noab106
Article PubMed PubMed Central Google Scholar
Goldbrunner R, Stavrinou P, Jenkinson MD, Sahm F, Mawrin C, Weber DC et al (2021) EANO guideline on the diagnosis and management of meningiomas. Neuro Oncol 23(11):1821–34. https://doi.org/10.1093/neuonc/noab150
Article PubMed PubMed Central Google Scholar
Marchetti M, Sahgal A, De Salles AAF, Levivier M, Ma L, Paddick I et al (2020) Stereotactic radiosurgery for intracranial noncavernous sinus benign meningioma: international stereotactic radiosurgery society systematic review, meta-analysis and practice guideline. Neurosurgery 87(5):879–890. https://doi.org/10.1093/neuros/nyaa169
Article PubMed PubMed Central Google Scholar
Lee CC, Trifiletti DM, Sahgal A, DeSalles A, Fariselli L, Hayashi M et al (2018) Stereotactic radiosurgery for benign (World health organization grade I) cavernous sinus meningiomas-international stereotactic radiosurgery society (ISRS) practice guideline: a systematic review. Neurosurgery 83(6):1128–1142. https://doi.org/10.1093/neuros/nyy009
Shinya Y, Hasegawa H, Shin M, Kawashima M, Umekawa M, Katano A et al (2023) Long-term outcomes of stereotactic radiosurgery for postoperative world health organization grade I skull base meningioma: utility of Ki-67 labeling index as a prognostic indicator. Neurosurgery 93(5):1144–1153. https://doi.org/10.1227/neu.0000000000002546
Sheehan J, Pikis S, Islim AI, Chen CJ, Bunevicius A, Peker S et al (2022) An international multicenter matched cohort analysis of incidental meningioma progression during active surveillance or after stereotactic radiosurgery: the IMPASSE study. Neuro Oncol 24(1):116–24. https://doi.org/10.1093/neuonc/noab132
Bir SC, Patra DP, Maiti TK, Bollam P, Minagar A, Nanda A (2017) Direct comparison of gamma knife radiosurgery and microsurgery for small size meningiomas. World Neurosurg 101:170–179. https://doi.org/10.1016/j.wneu.2017.01.105
Kuhn EN, Taksler GB, Dayton O, Loganathan AG, Vern-Gross TZ, Bourland JD et al (2013) Patterns of recurrence after stereotactic radiosurgery for treatment of meningiomas. Neurosurg Focus 35(6):E14. https://doi.org/10.3171/2013.8.Focus13283
Champeaux C, Houston D, Dunn L, Resche-Rigon M (2019) Intracranial WHO grade I meningioma: a competing risk analysis of progression and disease-specific survival. Acta Neurochir (Wien). https://doi.org/10.1007/s00701-019-04096-9
Yeon EK, Sung JY, Do SI, Park BJ, Kim EJ, Na K (2019) Clinicoradiological features of recurrent meningioma with high grade transformation. Anticancer Res 39(11):6299–6305. https://doi.org/10.21873/anticanres.13840
Ketter R, Henn W, Niedermayer I, Steilen-Gimbel H, König J, Zang KD, Steudel WI (2001) Predictive value of progression-associated chromosomal aberrations for the prognosis of meningiomas: a retrospective study of 198 cases. J Neurosurg 95(4):601–607. https://doi.org/10.3171/jns.2001.95.4.0601
Al-Mefty O, Kadri PA, Pravdenkova S, Sawyer JR, Stangeby C, Husain M (2004) Malignant progression in meningioma: documentation of a series and analysis of cytogenetic findings. J Neurosurg 101(2):210–218. https://doi.org/10.3171/jns.2004.101.2.0210
Choudhury A, Magill ST, Eaton CD, Prager BC, Chen WC, Cady MA et al (2022) Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat Genet 54(5):649–659. https://doi.org/10.1038/s41588-022-01061-8
Article PubMed PubMed Central Google Scholar
Wang JZ, Patil V, Landry AP, Gui C, Ajisebutu A, Liu J et al (2024) Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma. Nat Med 30(11):3173–3183. https://doi.org/10.1038/s41591-024-03167-4
Article PubMed PubMed Central Google Scholar
Patel AJ, Wan YW, Al-Ouran R, Revelli JP, Cardenas MF, Oneissi M et al (2019) Molecular profiling predicts meningioma recurrence and reveals loss of DREAM complex repression in aggressive tumors. Proc Natl Acad Sci U S A 116(43):21715–21726. https://doi.org/10.1073/pnas.1912858116
Article PubMed PubMed Central Google Scholar
Nassiri F, Liu J, Patil V, Mamatjan Y, Wang JZ, Hugh-White R et al (2021) A clinically applicable integrative molecular classification of meningiomas. Nature 597(7874):119–125. https://doi.org/10.1038/s41586-021-03850-3
Article PubMed PubMed Central Google Scholar
Hirano Y, Miyawaki S, Sakai Y, Teranishi Y, Okano A, Umekawa M et al (2024) Genetic analysis of foramen magnum meningiomas reveals AKT1 mutations uncomplicated by TRAF7 mutations. Acta Neuropathol Commun 12(1):123. https://doi.org/10.1186/s40478-024-01835-7
Article PubMed PubMed Central Google Scholar
Hirano Y, Miyawaki S, Sakai Y, Teranishi Y, Umekawa M, Hirata T et al (2025) Integrated molecular and detailed anatomical profiling identifies a prognostically adverse subtype of posterior fossa meningiomas: high-risk copy number alterations are associated with midline predilection and predict poor prognosis. Acta Neuropathol Commun 13(1):168. https://doi.org/10.1186/s40478-025-02083-z
Article PubMed PubMed Central Google Scholar
Sahm F, Aldape KD, Brastianos PK, Brat DJ, Dahiya S, von Deimling A et al (2025) cIMPACT-NOW update 8: clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas. Neuro Oncol 27(2):319–330. https://doi.org/10.1093/neuonc/noae170
Wang JZ, Patil V, Liu J, Dogan H, Tabatabai G, Yefet LS et al (2023) Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas. Acta Neuropathol 146(1):145–162. https://doi.org/10.1007/s00401-023-02571-3
Article PubMed PubMed Central Google Scholar
Khan AB, English CW, Chen WC, Athukuri P, Bayley JCt, Brandt VL et al (2023) Even heterozygous loss of CDKN2A/B greatly accelerates recurrence in aggressive meningioma. Acta Neuropathol 145(4):501–503. https://doi.org/10.1007/s00401-023-02543-7
Article PubMed PubMed Central Google Scholar
Driver J, Hoffman SE, Tavakol S, Woodward E, Maury EA, Bhave V et al (2022) A molecularly integrated grade for meningioma. Neuro Oncol 24(5):796–808. https://doi.org/10.1093/neuonc/noab213
Goutagny S, Yang HW, Zucman-Rossi J, Chan J, Dreyfuss JM, Park PJ et al (2010) Genomic profiling reveals alternative genetic pathways of meningioma malignant progression dependent on the underlying NF2 status. Clin Cancer Res 16(16):4155–64. https://doi.org/10.1158/1078-0432.Ccr-10-0891
Berghaus N, Hielscher T, Savran D, Schrimpf D, Maas SLN, Preusser M et al (2025) Meningiomas: sex-specific differences and prognostic implications of a chromosome X loss. Neuro Oncol 27(4):1019–28. https://doi.org/10.1093/neuonc/noae239
Juratli TA, Thiede C, Koerner MVA, Tummala SS, Daubner D, Shankar GM et al (2017) Intratumoral heterogeneity and TERT promoter mutations in progressive/higher-grade meningiomas. Oncotarget 8(65):109228–37. https://doi.org/10.18632/oncotarget.22650
Article PubMed PubMed Central Google Scholar
Schiffer D, Ghimenti C, Fiano V (2005) Absence of histological signs of tumor progression in recurrences of completely resected meningiomas. J Neurooncol 73(2):125–130. https://doi.org/10.1007/s11060-004-4207-4
Krayenbühl N, Pravdenkova S, Al-Mefty O (2007) De novo versus transformed atypical and anaplastic meningiomas: comparisons of clinical course, cytogenetics, cytokinetics, and outcome. Neurosurgery 61(3):495–503. https://doi.org/10.1227/01.Neu.0000290895.92695.22
Comments (0)