Background Fenugreek is known to improve muscle strength, stamina and serum testosterone level during resistance training.

Objectives A randomized, double blind, placebo controlled, comparative, interventional, prospective clinical study was conducted to evaluate efficacy and safety of a botanical extract of Fenugreek in Male Subjects during resistance training.

Methods Subjects were advised to take given product (FENUDAATTM or matching placebo) in a dose of 1 capsule (275 mg) twice daily after meals with water for 8 weeks. A total of 43 healthy participants (22 in FENUDAATTM group and 21 in placebo group) completed the study. Study subjects participated in a supervised 4-day per week resistance-training program for 8 weeks. The efficacy testing outcomes included serum testosterone (total) level, muscle strength and repetitions to failure, metabolic markers for anabolic activity (serum creatinine and blood urea nitrogen), and body fat percentage. Standard safety measurements such as adverse events monitoring, vital signs, hematology and biochemistry were performed.

Results A significant increase in 1 Repeat Measure (RM) Bench Press, 1 RM Leg Press responses and repetitions to failure in bench press and leg press was observed in the FENUDAATTM group, compared to Placebo group. A significant reduction in weight and BMI was observed in the FENUDAATTM group, compared to placebo group. A significant increase in total serum testosterone, strength, stamina, energy, and endurance was observed in the FENUDAATTM group, compared to placebo group. FENUDAATTM was safe and well tolerated as there were no adverse events reported.

Conclusion The study concludes that regular consumption of the FENUDAATTM Capsule improves serum testosterone, strength, stamina, energy, and endurance during resistance training.

The authors have declared no competing interest.

CTRI/2021/07/034548

The study was funded by Lodaat Pharma, 1415 West 22nd Street-Tower Floor, Oak Brook, Illinois 60523 both financially and materially.

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Institutional, KVTR Ayurveda College and Hospital, Boradi, Dhule District, India. (Letter no. AMB/331/2021-22 dated 22/06/2021)

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Yes

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The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.