Semin Plast Surg 2025; 39(03): 181-189
DOI: 10.1055/s-0045-1810065

1   Department of Plastic and Reconstructive Surgery, Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan

,

Madonna Rica Anggelia   *

1   Department of Plastic and Reconstructive Surgery, Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan

,

Hui-Yun Cheng

1   Department of Plastic and Reconstructive Surgery, Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan

,

Fu-Chan Wei

1   Department of Plastic and Reconstructive Surgery, Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan

,

Cheng-Hung Lin

1   Department of Plastic and Reconstructive Surgery, Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan

› Author Affiliations
Funding This work was supported by grants from the National Science and Technology Council of Taiwan (grant nos.: NSTC 112-2314-B-182A-038-MY3, 112-2326-B-182A-002-MY2, and 113-2811-B-182A-013) and Chang Gung Medical Foundation (grant no.: CPRPG3M0021-3). › Further InformationAlso available at   Buy Article Permissions and Reprints Abstract

Vascularized composite allotransplantation (VCA) represents one of the most complex frontiers in reconstructive surgery, requiring simultaneous transfer of multiple tissue types, including skin, muscle, bone, and nerves. Success depends on the multidisciplinary integration of immunology, surgery, rehabilitation, and psychology. Chang Gung Memorial Hospital has established itself as a pioneer in clinical VCA in Taiwan, contributing significantly through innovative basic research and successful clinical outcomes. This review explores our institutional experience, highlighting clinical cases and groundbreaking preclinical research within our comprehensive VCA program.

Keywords vascularized composite allotransplantation - immunosuppression - tolerance induction - hand transplantation

*These authors contributed equally to this work.

Publication History

Article published online:
08 August 2025

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