The practice of neurology is undergoing significant transformation due to evolving economic pressures, workforce shortages, and increasing demand for neurologic care. Lower reimbursements, increasing operating expenses, and complexity of care challenge the sustainability of existing practice models. This study outlines critical considerations for practice and staffing models in neurology, focusing on strategies to optimize access to care, contain costs for patients and the practice, and enhance operational efficiency. Key topics discussed include integrating advanced practice providers, expanding teleneurology and intravisit care, exploring value-based care models, and enhancing workflows via technology to improve patient experience and clinic efficiency. As the field continues to evolve, neurology practices must adopt agile strategies that balance clinical excellence with economic sustainability in order to meet the demands of a challenging healthcare landscape.