Analysis of whole-exome data of nonobese NAFLD patients from India reveals association with new markers on functionally relevant genes and pathways

Ahrens M., Ammerpohl O., Von Schönfels W., Kolarova J., Bens S., Itzel T. et al. 2013 DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery. Cell Metabol. 18, 296e302.

Article  Google Scholar 

Albhaisi S., Chowdhury A. and Sanyal A. J. 2019 Non-alcoholic fatty liver disease in lean individuals. JHEP Rep. 1, 329–341.

Article  PubMed  PubMed Central  Google Scholar 

Anstee Q. M., Daly A. K. and Day C. P. 2011 Genetic modifiers of non-alcoholic fatty liver disease progression. Biochim. Biophys. Acta 1812, 1557–1566.

Article  CAS  PubMed  Google Scholar 

Baker S. S., Baker R. D., Liu W., Nowak N. J. and Zhu L. 2010 Role of alcohol metabolism in non-alcoholic steatohepatitis. PLoS One 5, e9570.

Article  PubMed  PubMed Central  Google Scholar 

Benjamini Y. and Hochberg Y. 1995 Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy. Statistical Soc. Ser. B (Methodological) 57, 289–300.

Article  Google Scholar 

Cao Y., Wang T., Wu Y., Juan J., Qin X., Tang X. et al. 2018 Opposite genetic effects of CMIP polymorphisms on the risk of type 2 diabetes and obesity: a family-based study in China. Int. J. Mol. Sci. 19, 1011.

Article  PubMed  PubMed Central  Google Scholar 

Gadd V. L., Patel P. J., Jose S., Horsfall L., Powell E. E. and Irvine K. M. 2016 Altered peripheral blood monocyte phenotype and function in chronic liver disease: implications for hepatic recruitment and systemic inflammation. PLoS One 11, e0157771.

Article  PubMed  PubMed Central  Google Scholar 

Ghosh S., Barik A., Majumder S., Gorain A., Mukherjee S., Mazumdar S. et al. 2015 Health and demographic surveillance system profile: the Birbhum population project (Birbhum HDSS). Int. J. Epidemiol. 44, 98–107.

Article  PubMed  Google Scholar 

Glickman M. E., Rao S. R. and Schultz M. R. 2014 False discovery rate control is a recommended alternative to Bonferroni-type adjustments in health studies. J. Clin. Epidemiol. 67, 850–857.

Article  PubMed  Google Scholar 

Gobeil E., Abner E., Ghodsian N., Taba N., St-Amand A., Perrot N. et al. 2021 Genome-wide meta-analysis and mendelian randomization identify early biomarkers of non-alcoholic fatty liver disease. J. Endocr. Soc. 5 (suppl 1), A315.

Article  PubMed Central  Google Scholar 

Grimaudo S., Pipitone R. M., Pennisi G., Celsa C., Cammà C., Di Marco V. et al. 2020 Association between PNPLA3 rs738409 C>G variant and liver-related outcomes in patients with nonalcoholic fatty liver disease. Clin. Gastroenterol. Hepatol. 18, 935–944.

Article  CAS  PubMed  Google Scholar 

He L, Deng T, Luo HS (2015) Alcohol dehydrogenase 1C (ADH1C) gene polymorphism and alcoholic liver cirrhosis risk: a meta analysis. Int. J. Clin. Exp. Med. 8, 11117–11124.

CAS  PubMed  PubMed Central  Google Scholar 

Hotta K., Kitamoto T., Kitamoto A., Ogawa Y., Honda Y., Kessoku T. et al. 2018 Identification of the genomic region under epigenetic regulation during non-alcoholic fatty liver disease progression. Hepatol. Res. 48, E320–E334.

Article  CAS  PubMed  Google Scholar 

Hou C. Y., Ma C. Y., Lin Y. J., Huang C. L., Wang H. D., Yuh C. H. 2022 WNK1-OSR1 signaling regulates angiogenesis-mediated metastasis towards developing a combinatorial anti-cancer strategy. Int. J. Mol. Sci. 23, 12100.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jonas W. and Schürmann A. 2021 Genetic and epigenetic factors determining NAFLD risk. Mol. Metab. 50, 101111.

Article  CAS  PubMed  Google Scholar 

Kim D. J., Yoon S., Ji S., Yang J., Kim Y.-K., Lee S. H. et al. 2018 Ursodeoxycholic acid improves liver function via phenylalanine/tyrosine pathway and microbiome remodelling in patients with liver dysfunction. Sci. Rep. 8, 11874.

Article  PubMed  PubMed Central  Google Scholar 

Lake A. D., Novak P., Fisher C. D., Jackson J. P., Hardwick R. N., Billheimer D. D. et al. 2011 Analysis of global and absorption, distribution, metabolism, and elimination gene expression in the progressive stages of human nonalcoholic fatty liver disease. Drug Metab. Dispos. 39, 1954–1960.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lam T. K., Gutierrez-Juarez R., Pocai A. and Rossetti L. 2005 Regulation of blood glucose by hypothalamic pyruvate metabolism. Science 309, 943–947.

Article  CAS  PubMed  Google Scholar 

Lee J., Song J. H., Park J. H., Chung M. Y., Lee S. H., Jeon S. B. et al. 2023 Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis. Exp. Mol. Med. 55, 143–157.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li L., Huang Y. T., Wang L. T,.. Wang X. L., Chen Z. Y., Jiang S. L., Zeng Q. L., Huang H. P., Li X. L. 2024 ADH4-a potential prognostic marker for hepatocellular carcinoma with possible immune-related implications. BMC Cancer 24, 927.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu L., Liao R., Wu Z., Du C., You Y., Que K., Duan Y., Yin K., Ye W. 2022 Hepatic stellate cell exosome-derived circWDR25 promotes the progression of hepatocellular carcinoma via the miRNA-4474-3P-ALOX-15 and EMT axes. Biosci Trends 16, 267–281.

Article  CAS  PubMed  Google Scholar 

Moran-Salvador E. and Mann J. 2017 Epigenetics and liver fibrosis. Cell. Mol. Gastroenterol. Hepatol. 4, 125–134.

Article  PubMed  PubMed Central  Google Scholar 

Pettinelli P., Arendt B. M., Teterina A., McGilvray I., Comelli E. M., Fung S. K. et al. 2018 Altered hepatic genes related to retinol metabolism and plasma retinol in patients with non-alcoholic fatty liver disease. PLoS One 13, e0205747.

Article  PubMed  PubMed Central  Google Scholar 

Pingitore P. and Romeo S. 2019 The role of PNPLA3 in health and disease. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1864, 900–906.

Article  CAS  PubMed  Google Scholar 

Pirola C. J., Gianotti T. F., Castaño G. O., Mallardi P., Martino J. S., Ledesma M. M. G. L. et al. 2015 Circulating microRNA signature in nonalcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis. Gut 64, 800–812.

Article  CAS  PubMed  Google Scholar 

Romeo S., Kozlitina J., Xing C., Pertsemlidis A., Cox D., Pennacchio L. A. et al. 2008 Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat. Genet. 40, 1461–1465.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rouillard A. D., Gundersen G. W., Fernandez N. F., Wang Z., Monteiro C. D., McDermott M. G. et al. 2016 The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins. Database, https://doi.org/10.1093/database/baw100.

Article  PubMed  PubMed Central  Google Scholar 

Saadeh S., Younossi Z. M., Remer E. M., Gramlich T., Ong J. P., Hurley M. et al. 2002 The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology 123, 745–750.

Article  PubMed  Google Scholar 

Salari N., Darvishi N., Mansouri K., Ghasemi H., Hosseinian-Far M., Darvishi F. et al. 2021 Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease: a systematic review and meta-analysis. BMC Endocr. Disord. 21, 125.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sulaiman S. A., Dorairaj V. and Adrus M. N. H. 2022 Genetic polymorphisms and diversity in nonalcoholic fatty liver disease (NAFLD): a mini review. Biomedicines 11, 106.

Article  PubMed  PubMed Central  Google Scholar 

Tang S., Zhang J., Mei T. T., Guo H., Wei X. H., Zhang W. Y. et al. 2020 Association of PNPLA3 rs738409 G/C gene polymorphism with nonalcoholic fatty liver disease in children: a meta-analy

Comments (0)

No login
gif