Funding

This project was supported by Otsuka Pharmaceutical.

Conflicts of Interest

Dr. Neugut has consulted for Otsuka, GlaxoSmithKline, Eisai, United Biosource Corp, Hospira, Value Analytics, and Merck and receives grant support from Otsuka and Kyowa Kirin. Dr. George and Ms. Lebo are employees of Otsuka. Dr. Jacobson receives grant support from Otsuka and Kyowa Kirin. Dr. Parkinson is the Principal of P3 Health, LLC. and serves on numerous boards related to pharmaceuticals. Ms. Segall and Dr. Bransas have no relevant conflicts to declare. Dr. Freedberg has consulted for Ferring and KeepBio and receives grant support from Otsuka, Kyowa Kirin, and Seres Therapeutics. Dr. Rahman is an employee of Cybin, a former employee of Otsuka, and has done extensive consulting.

Ethics Approval

Not applicable.

Consent to Participate

Not applicable.

Consent for Publication

Not applicable.

Availability of Data and Material

Not applicable.

Code Availability

Not applicable.

Authors' Contributions

AN and MR conceived the project. AN, DF, and MR drafted the initial manuscript. VG and ML provided funding. All authors were involved in the project and in critically revising the manuscript.