Alam MM, Kariya R, Kawaguchi A, et al. 2016 Inhibition of autophagy by chloroquine induces apoptosis in primary effusion lymphoma in vitro and in vivo through induction of endoplasmic reticulum stress. Apoptosis 21 1191–1201

Article  Google Scholar 

Altulea D, Maassen S, Baranov MV, et al. 2021 What makes (hydroxy) chloroquine ineffective against COVID-19: insights from cell biology. J. Mol. Cell Biol. 13 175–184

Article  CAS  PubMed  PubMed Central  Google Scholar 

Amaravadi RK, Lippincott-Schwartz J, Yin X, et al. 2011 Principles and current strategies for targeting autophagy for cancer treatment. Clin. Cancer Res. 17 654–666

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bond MR, Ghosh SK, Wang P, et al. 2014 Conserved nutrient sensor O-GlcNAc transferase is integral to C. elegans pathogen-specific immunity. PLoS One 9 e113231

Chen D, Xie J, Fiskesund R, et al. 2018 Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype. Nat. Commun. 9 873

Article  PubMed  PubMed Central  Google Scholar 

Costa EA, Goncalves AP, Batista JAD, et al. 2022 New insights into the mechanism of action of the drug chloroquine: direct interaction with DNA and cytotoxicity. J. Phys. Chem. B 126 3512–3521

Article  CAS  PubMed  Google Scholar 

Das P, Aballay A and Singh J 2024 Calcineurin inhibition enhances Caenorhabditis elegans lifespan by defecation defects-mediated calorie restriction and nuclear hormone signaling. eLife 12 RP89572

Della Porta A, Bornstein K, Coye A, et al. 2020 Acute chloroquine and hydroxychloroquine toxicity: a review for emergency clinicians. Am. J. Emerg. Med. 38 2209–2217

Article  PubMed  PubMed Central  Google Scholar 

Di Trani L, Savarino A, Campitelli L, et al. 2007 Different pH requirements are associated with divergent inhibitory effects of chloroquine on human and avian influenza A viruses. Virol. J. 4 39

Article  PubMed  PubMed Central  Google Scholar 

Doyno C, Sobieraj DM and Baker WL 2021 Toxicity of chloroquine and hydroxychloroquine following therapeutic use or overdose or overdose. Clin. Toxicol. 59 12–23

Article  CAS  Google Scholar 

Ektorp E 2020 Death threats after a trial on chloroquine for COVID-19. Lancet Infect. Dis. 20 661

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eng CH, Wang Z, Tkach D, et al. 2016 Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy. Proc. Natl. Acad. Sci. USA 113 182–187

Article  CAS  PubMed  Google Scholar 

Funnell SGP, Dowling WE, Gsell P, et al. 2020 Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients. Nat. Commun. 11 4253

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gasmi A, Peana M, Noor S, et al. 2021 Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story. Appl. Microbiol. Biotechnol. 105 1333–1343

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghosh A and Singh J 2024 Translation initiation or elongation inhibition triggers contrasting effects on Caenorhabditis elegans survival during pathogen infection. mBio 15 e02485-24

Gokul G and Singh J 2022 Dithiothreitol causes toxicity in C. elegans by modulating the methionine-homocysteine cycle. eLife 11 e76021

Grove CA, De Masi F, Barrasa MI, et al. 2009 A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138 314–327

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hempelmann E 2007 Hemozoin biocrystallization in Plasmodium falciparum and the antimalarial activity of crystallization inhibitors. Parasitol. Res. 100 671–676

Article  PubMed  Google Scholar 

Homewood CA, Warhurst DC, Peters W, et al. 1972 Lysosomes, pH and the anti-malarial action of chloroquine. Nature 235 50–52

Article  CAS  PubMed  Google Scholar 

Hu C, Solomon VR, Ulibarri G, et al. 2008 The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine. Bioorg. Med. Chem. 16 7888–7893

Article  CAS  PubMed  Google Scholar 

Hulsen T, de Vlieg J and Alkema W 2008 BioVenn – a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams. BMC Genomics 9 488

Article  PubMed  PubMed Central  Google Scholar 

Jia B, Xue Y, Yan X, et al. 2018 Autophagy inhibitor chloroquine induces apoptosis of cholangiocarcinoma cells via endoplasmic reticulum stress. Oncol. Lett. 16 3509–3516

PubMed  PubMed Central  Google Scholar 

Joshi J, McCauley MJ, Morse M, et al. 2024 Mechanism of DNA intercalation by chloroquine provides insights into toxicity. Int. J. Mol. Sci. 25 1410

Article  CAS  PubMed  PubMed Central  Google Scholar 

Keyaerts E, Li S, Vijgen L, et al. 2009 Antiviral activity of chloroquine against human coronavirus OC43 infection in newborn mice. Antimicrob. Agents Chemother. 53 3416–3421

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim DH, Feinbaum R, Alloing G, et al. 2002 A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science 297 623–626

Article  CAS  PubMed  Google Scholar 

Kim DH, Liberati NT, Mizuno T, et al. 2004 Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase. Proc. Natl. Acad. Sci. USA 101 10990–10994

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kuznik A, Bencina M, Svajger U, et al. 2011 Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines. J. Immunol. 186 4794–4804

Article  CAS  PubMed  Google Scholar 

Lapierre LR, De Magalhaes Filho CD, McQuary PR, et al. 2013 The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Nat. Commun. 4 2267

Article  PubMed  Google Scholar 

Lee GH, Kim DS, Kim HT, et al. 2011 Enhanced lysosomal activity is involved in bax inhibitor-1-induced regulation of the endoplasmic reticulum (ER) stress response and cell death against ER stress. J. Biol. Chem. 286 24743–24753

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lei Z, Wu Z, Dong S, et al. 2020 Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-19. Pharmacol. Ther. 216 107672

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang DH, Choi DS, Ensor JE, et al. 2016 The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair. Cancer Lett. 376 249–258

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lie SO and Schofield B 1973 Inactivation of lysosomal function in normal cultured human fibroblasts by chloroquine. Biochem. Pharmacol. 22 3109–3114

Article  CAS  PubMed  Google Scholar 

Maharjan Y, Dutta RK, Son J, et al. 2022 Intracellular cholesterol transport inhibition impairs autophagy flux by decreasing autophagosome–lysosome fusion. Cell Commun. Signal. 20 189

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mallo GV, Le C, Couillault C, et al. 2002 Inducible antibacterial defense system in C. elegans. Curr. Biol. 12 1209–1214

Article