Available online 5 March 2024, 155252

Author links open overlay panel, , , , , , , , , , , ABSTRACT

Necroptosis, a controlled type of cell death that is different from apoptosis, has become a key figure in the aetiology of cancer and offers a possible target for treatment. A growing number of biological activities, including necroptosis, have been linked to long noncoding RNAs (lncRNAs), a varied family of RNA molecules with limited capacity to code for proteins. The complex interactions between LncRNAs and important molecular effectors of necroptosis, including mixed lineage kinase domain-like pseudokinase (MLKL) and receptor-interacting protein kinase 3 (RIPK3), will be investigated. We will explore the many methods that LncRNAs use to affect necroptosis, including protein-protein interactions, transcriptional control, and post-transcriptional modification. Additionally, the deregulation of certain LncRNAs in different forms of cancer will be discussed, highlighting their dual function in influencing necroptotic processes as tumour suppressors and oncogenes. The goal of this study is to thoroughly examine the complex role that LncRNAs play in controlling necroptotic pathways and how that regulation affects the onset and spread of cancer. In the necroptosis for cancer treatment, this review will also provide insight into the possible therapeutic uses of targeting LncRNAs. Techniques utilising LncRNA-based medicines show promise in controlling necroptotic pathways to prevent cancer from spreading and improve the effectiveness of treatment.

Section snippetsINTRODUCTION

Maintaining cellular homeostasis is largely dependent on the complex control of cell death pathways, and disruption of these mechanisms is a hallmark of cancer [1.], [2.]. Necroptosis is one of the several ways that cells can die, and it has special significance for cancer biology [3]. Necroptosis, which is defined as controlled necrotic cell death, is known to be an important component in the orchestration of cellular death, and dysregulation of it has been linked to several clinical

NECROPTOSIS IN CANCER

Necroptosis has been identified as a critical modulator of cellular homeostasis, with complex consequences for the initiation and spread of cancer [10]. Necroptosis, in contrast to apoptosis, is characterised by a tightly controlled series of molecular processes that lead to the death of cells [22.], [31.]. Necroptosis is regulated by several important molecular effectors, namely MLKL, RIPK1, and RIPK3. These chemicals take part in cellular signalling pathways in a physiologically appropriate

LNCRNAS AND THEIR REGULATORY ROLES IN CELLULAR REGULATION

LncRNAs, which were formerly thought to be transcriptional noise, are now essential components of the complex cellular control symphony [55.], [56.], [57.]. Their varied roles in gene expression, epigenetic control, and cellular activities go far beyond the conventional understanding of RNA as only a messenger [58.], [59.], [60.]. Deciphering the complex world of LncRNAs offers a valuable understanding of their possible function in controlling important cellular processes, such as necroptosis

Breast cancer

The most common disease in women, breast cancer is caused by abnormal cell development in the breast tissues [86]. It presents in a variety of subgroups, each with unique traits and therapeutic modalities [87]. Treatment effectiveness is improved by early detection through tests like mammograms [88]. Treatment options include targeted treatments, chemotherapy, and surgery, with a focus on personalised care [89.], [90.]. Due to the intricate aetiology of breast cancer, which includes hormonal,

FUTURE DIRECTIONS AND CHALLENGES

A new field of study examines possible improvements in our knowledge of the relationships between LncRNA and necroptosis. Research has revealed that lncRNAs are involved in several biological processes, including necroptosis and other causes of cell death. Necroptosis-related lncRNAs have been discovered in recent research, and their possible effects on cancer prognosis and treatment have been explored. One research on glioma patients, for example, found lncRNAs associated with necroptosis that

CONCLUSION

Investigating LncRNAs in necroptosis reveals a multifaceted and intricate environment with significant implications for the pathophysiology of cancer and treatment strategies. Through study, important functions of some LncRNAs in controlling necroptotic processes have been revealed, which impact cancer start, progression, and response to therapy. In summary, LncRNAs play a crucial role in regulating the equilibrium between cell survival and necroptosis in cancerous cells. Their dysregulation

CRediT authorship contribution statement

Omar Hafiz Haj Ali: Writing – review & editing, Validation. Satheesh Kumar G: Investigation, Formal analysis, Data curation, Conceptualization. Nancy Mohammad Elafandy: Validation, Supervision. Randa Abdeen Husien Abdalla: Visualization, Resources. Maali D. Alshammari: Writing – review & editing, Investigation. S. Afsar: Data curation, Conceptualization. Nayla Ahmed Mohammed Aboshouk: Methodology, Investigation. Rahamat Unissa Syed: Formal analysis, Data curation. Amna Abakar Suleiman Khalifa:

Declaration of Competing Interest

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests.

View full text

© 2024 Elsevier GmbH. All rights reserved.