Lee SL (2012) Radioactive iodine therapy. Curr Opin Endocrinol Diabetes Obes 19:420–428

Article  CAS  PubMed  Google Scholar 

Spitzweg C, Joba W, Schriever K et al (1999) Analysis of human sodium iodide symporter immunoreactivity in human exocrine glands. J Clin Endocrinol Metab 84:4178–4184

CAS  PubMed  Google Scholar 

Bakheet SM, Hammami MM, Hemidan A et al (1998) Radioiodine secretion in tears. J Nucl Med 39:1452–1454

CAS  PubMed  Google Scholar 

Solans R, Bosch JA, Galofré P et al (2001) Salivary and lacrimal gland disfunction (sicca syndrome) after radioiodine therapy. J Nuc Med 42:738–743

CAS  Google Scholar 

Sakahara H, Yamashita S, Suzuki K et al (2007) Visualization of nasolacrimal drainage system after radioiodine therapy in patients with thyroid cancer. Ann Nucl Med 21:525–527

Article  PubMed  Google Scholar 

Kloos RT, Duvuuri V, Jhiang SM et al (2002) Nasolacrimal drainage system obstruction from radioactive iodine therapy for thyroid carcinoma. J Clin Endocrinol Metab 87:5817–5820

Article  CAS  PubMed  Google Scholar 

Zettinig G, Hanselmayer G, Fueger BJ et al (2002) Long-term impairment of the lacrimal glands after radioiodine therapy: a crosssectional study. Eur J Nucl Med Mol Imaging 29:1428–1432

Article  CAS  PubMed  Google Scholar 

Bonnema SJ, Hegedüs L (2012) Radioiodine therapy in benign thyroid diseases: effects, side effects, and factors affecting therapeutic outcome. Endocr Rev 33(6):920–980

Article  CAS  PubMed  Google Scholar 

Koca G, Acar U, Atilgan HI et al (2013) Changes in conjunctival cytology and tear function tests with radioiodine treatment for hyperthyroidism. Ann Nucl Med 27:694–699

Article  CAS  PubMed  Google Scholar 

Dardalas I, Stamoula E, Rigopoulos P et al (2019) Dexmedetomidine effects in different experimental sepsis in vivo models. Eur J Pharmacol 856:172401

Article  CAS  PubMed  Google Scholar 

Kismet K, Sadic M, Bag YM, et al. (2016) Hepatoprotective effect of Dexmedetomidine against radioiodine toxicity in rats: evaluation of oxidative status and histopathological changes. Int Surg

Liang H, Liu HZ, Wang HB et al (2017) Dexmedetomidine protects against cisplatin-induced acute kidney injury in mice through regulating apoptosis and inflammation. Inflamm Res 66(5):399–411

Article  CAS  PubMed  Google Scholar 

Smith TA, Kirkpatrick DR, Smith S et al (2017) Radioprotective agents to prevent cellular damage due to ionizing radiation. J Transl Med 15(1):232

Article  PubMed  PubMed Central  Google Scholar 

Engelhard K, Werner C, Eberspächer E et al (2003) The effect of the alpha 2-agonist Dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats. Anesth Analg 96(2):524–531

CAS  PubMed  Google Scholar 

Çınar S, Tümkaya L, Mercantepe T et al (2021) Can Dexmedetomidine be effective in the protection of radiotherapy-induced brain damage in the rat? Neurotox Res 39(4):1338–1351

Article  PubMed  Google Scholar 

Kucuk A, Yaylak F, Cavunt-Bayraktar A et al (2014) The protective effects of Dexmedetomidine on hepatic ischemia reperfusion injury. Bratisl Lek Listy 115(11):680–684

CAS  PubMed  Google Scholar 

Kuru S, Barlas AM, Bozkirli B et al (2014) The protective effects of Dexmedetomidine on the liver against obstructive jaundice in rats. Acta Medica Mediterranea 30:1255–1262

Google Scholar 

Wang H, Hu B, Zou Y et al (2014) Dexmedetomidine premedication attenuates concanavalin A-induced hepatitis in mice. J Toxicol Sci 39(5):755–764

Article  CAS  PubMed  Google Scholar 

Damato BE, Allan D, Murray SB, Lee WR (1984) Senile atrophy of the human lacrimal gland: the contribution of chronic inflammatory disease. Br J Ophthalmol 68(9):674–680

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rios JD, Horikawa Y, Chen LL et al (2005) Age-dependent alterations in mouse exorbital lacrimal gland structure, innervation and secretory response. Exp Eye Res 80(4):477–491

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koca G, Singar E, Akbulut A et al (2021) The effect of resveratrol on radioiodine therapy-associated lacrimal gland damage. Curr Eye Res 46(3):398–407

Article  CAS  PubMed  Google Scholar 

Erel O (2004) A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 37(4):277–285

Article  CAS  PubMed  Google Scholar 

Erel O (2005) A new automated colorimetric method for measuring total oxidand status. Clin Biochem 38(12):1103–1111

Article  CAS  PubMed  Google Scholar 

Citrin D, Cotrim AP, Hyodo F et al (2010) Radioprotectors and mitigators of radiation-induced normal tissue injury. Oncologist 15(4):360–371

Article  PubMed  PubMed Central  Google Scholar 

Li C, Wright MM, Jackson RM (2002) Reactive species mediated injury of human lung epithelial cells after hypoxia-reoxygenation. Exp Lung Res 28(5):373–389

Article  PubMed  Google Scholar 

McCord JM (1985) Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 312(3):159–163

Article  CAS  PubMed  Google Scholar 

Naziroğlu M, Simşek M, Kutlu M (2004) Moderate exercise with a dietary vitamin C and E combination protects against streptozotocin-induced oxidative damage to the blood and improves fetal outcomes in pregnant rats. Clin Chem Lab Med 42(5):511–517

Article  PubMed  Google Scholar 

Eren L, Naziroglu M, Demirdas A (2007) Protectice effects of lamotrigine, aripiprazole and escitalopramon depression­ induced oxidative stress in ratbrain. Neurochem Res 32(7):1188–1195

Article  CAS  PubMed  Google Scholar 

Baysal Z, Togrul T, Aksoy N et al (2009) Evaluation of total oxidative and antioxidative status in pediatric patients undergoing laparoscopic surgery. J Pediatr Surg 44(7):1367–1370

Article  PubMed  Google Scholar 

Jones BM, Kwok CC, Kung AW (1999) Effect of radioactive iodine therapy on cytokine production in Graves’ disease: transient increases in interleukin-4 (IL-4), IL-6, IL-10, and tumor necrosis factor-alpha, with longer term increases in interferon-gamma production. J Clin Endocrinol Metab 84:4106–4110

CAS  PubMed  Google Scholar 

Williams RM, Singh J, Sharkey KA (1994) Innervation and mast cells of the rat exorbital lacrimal gland: the effect of age. J Auton Nerv Syst 47:95–108

Article  CAS  PubMed  Google Scholar 

Burd PR, Rogers HW, Gordon JR et al (1989) Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines. J Exp Med 170:245–257

Article  CAS  PubMed  Google Scholar 

Gordon JR, Galli SJ (1990) Mast cells as a source of both preformed and immunologically inducible TNFalpha/cachectin. Nature 346:274–276

Article  ADS  CAS  PubMed  Google Scholar 

Gordon JR, Galli SJ (1991) Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent biological responses. J Exp Med. 174:103–107

Article  CAS  PubMed  Google Scholar 

Jaatinen P, Koistinaho J, Hervonen A (1989) Age-related morphometric and histochemical features of rat sympathetic neurons. Adv Exp Med Biol 266:61–72

CAS  PubMed  Google Scholar 

Cuervo AM, Dice JF (2000) When lysosomes get old. Exp Gerontol 35:119–131

Article  CAS  PubMed  Google Scholar 

Cekic B, Geze S, Ozkan G et al (2014) The effect of Dexmedetomidine on oxidative stress during pneumoperitoneum. Biomed Res Int 2014:760323

Article  PubMed  PubMed Central  Google Scholar 

Shalini S, Dorstyn L, Dawar S et al (2015) Old, new and emerging functions of caspases. Cell Death Differ 22:526–539

Article  CAS  PubMed  Google Scholar 

Pordanjani SM, Hosseinimehr SJ (2016) The role of NF-kb inhibitors in cell response to radiation. Curr Med Chem 23(34):3951–3963

Article  CAS  PubMed  Google Scholar 

Yumusak N, Sadic M, Yucel G et al (2018) Apoptosis and cell proliferation in short-term and long-term effects of radioiodine-131-induced kidney damage: an experimental and immunohistochemical study. Nucl Med Commun 39(2):131–139

Article  CAS