Non-invasive differentiation of hepatic steatosis and steatohepatitis in a mouse model using nitroxyl radical as an MRI-contrast agent

AbbreviationsROS

reactive oxygen species

ESR

electron spin resonance

DNP-MRI

dynamic nuclear polarization-magnetic resonance imaging

MCD

methionine choline deficient

MRI

magnetic resonance imaging

PBS

phosphate buffered saline

CNR

contrast-to-noise ratio

NASH

non-alcoholic steatohepatitis

RARE

rapid acquisition with relaxation enhancement

AUC

area under the hepatic signal intensity change rate-time curve

NAFLD

non-alcoholic fatty liver disease

SAF-A score

the activity part of the Steatosis, Activity, and Fibrosis score

USPIOs,

ultrasmall superparamagnetic iron oxide particles

Keywords

Steatohepatitis

magnetic resonance imaging

nitroxyl radicals

reactive oxygen species

Data availability

Data will be made available on request.

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