Wang, S. et al. The mitophagy pathway and its implications in human diseases. Signal. Transduct. Target. Ther. 8, 304 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Su, L., Zhang, J., Gomez, H., Kellum, J. A. & Peng, Z. Mitochondria ROS and mitophagy in acute kidney injury. Autophagy 19, 401–414 (2023).

Article  CAS  PubMed  Google Scholar 

Tang, C., Livingston, M. J., Liu, Z. & Dong, Z. Autophagy in kidney homeostasis and disease. Nat. Rev. Nephrol. 16, 489–508 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vargas, J. N. S., Hamasaki, M., Kawabata, T., Youle, R. J. & Yoshimori, T. The mechanisms and roles of selective autophagy in mammals. Nat. Rev. Mol. Cell Biol. 24, 167–185 (2023).

Article  CAS  PubMed  Google Scholar 

Wang, Y. et al. Imbalanced lipid homeostasis caused by membrane αKlotho deficiency contributes to the acute kidney injury to chronic kidney disease transition. Kidney Int. 104, 956–974 (2023).

Article  CAS  PubMed  Google Scholar 

Jin, H. et al. DDRGK1-mediated ER-phagy attenuates acute kidney injury through ER-stress and apoptosis. Cell Death Dis. 15, 63 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Minami, S. et al. Lipophagy maintains energy homeostasis in the kidney proximal tubule during prolonged starvation. Autophagy 13, 1629–1647 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yamamoto, T. et al. Eicosapentaenoic acid attenuates renal lipotoxicity by restoring autophagic flux. Autophagy 17, 1700–1713 (2021).

Article  CAS  PubMed  Google Scholar 

Han, Y. et al. Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy. Cell Death Dis. 12, 1031 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miceli, C. et al. The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells. Nat. Cell Biol. 22, 1091–1102 (2020).

Article  CAS  PubMed  Google Scholar 

Cybulsky, A. V. The intersecting roles of endoplasmic reticulum stress, ubiquitin-proteasome system, and autophagy in the pathogenesis of proteinuric kidney disease. Kidney Int. 84, 25–33 (2013).

Article  CAS  PubMed  Google Scholar 

Navarro-Betancourt, J. R. et al. The unfolded protein response transducer IRE1α promotes reticulophagy in podocytes. Biochim. Biophys. Acta Mol. Basis Dis. 1868, 166391 (2022).

Article  CAS  PubMed  Google Scholar 

Cybulsky, A. V. et al. Deletion of IRE1α in podocytes exacerbates diabetic nephropathy in mice. Sci. Rep. 14, 11718 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gahlot, P. et al. Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH. Mol. Cell 84, 1556–1569.e10 (2024).

Article  CAS  PubMed  Google Scholar 

González, A. & Dikić, I. Decoding Golgiphagy: selective recycling under stress. Cell Res. 34, 277–278 (2024).

Article  PubMed  PubMed Central  Google Scholar 

Papandreou, M. E. & Tavernarakis, N. Nucleophagy: from homeostasis to disease. Cell Death Differ. 26, 630–639 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, X. C. et al. Lysosome depletion-triggered autophagy impairment in progressive kidney injury. Kidney Dis. 7, 254–267 (2021).

Article  Google Scholar 

Dusabimana, T. et al. GOLPH3 promotes endotoxemia-induced liver and kidney injury through Golgi stress-mediated apoptosis and inflammatory response. Cell Death Dis. 14, 458 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu, W. et al. GALNT3 in ischemia-reperfusion injury of the kidney. J. Am. Soc. Nephrol. 36, 348–360 (2025).

Article  PubMed  Google Scholar 

Gubas, A. & Dikic, I. A guide to the regulation of selective autophagy receptors. FEBS J. 289, 75–89 (2022).

Article  CAS  PubMed  Google Scholar 

Wirth, M. et al. Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins. Nat. Commun. 10, 2055 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Rogov, V. V. et al. Atg8 family proteins, LIR/AIM motifs and other interaction modes. Autophagy Rep. 2, 2188523 (2023).

Article  PubMed  PubMed Central  Google Scholar 

You, Z. et al. Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress. Nat. Commun. 10, 5792 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Russell, R. C. et al. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat. Cell Biol. 15, 741–750 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jung, C. H. et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol. Biol. Cell 20, 1992–2003 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, Y. et al. PINK1/Parkin-mediated mitophagy is activated in cisplatin nephrotoxicity to protect against kidney injury. Cell Death Dis. 9, 1113 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Tang, C. et al. Activation of BNIP3-mediated mitophagy protects against renal ischemia-reperfusion injury. Cell Death Dis. 10, 677 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Wang, J., Zhu, P., Li, R., Ren, J. & Zhou, H. Fundc1-dependent mitophagy is obligatory to ischemic preconditioning-conferred renoprotection in ischemic AKI via suppression of Drp1-mediated mitochondrial fission. Redox Biol. 30, 101415 (2020).

Article  CAS  PubMed  Google Scholar 

Yang, Y. et al. Activation of lipophagy is required for RAB7 to regulate ferroptosis in sepsis-induced acute kidney injury. Free. Radic. Biol. Med. 218, 120–131 (2024).

Article  CAS  PubMed  Google Scholar 

Pu, M. et al. ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover. Protein Cell 14, 653–667 (2023).

CAS  PubMed  PubMed Central  Google Scholar 

Chino, H., Hatta, T., Natsume, T. & Mizushima, N. Intrinsically disordered protein TEX264 mediates ER-phagy. Mol. Cell 74, 909–921.e6 (2019).

Article  CAS  PubMed  Google Scholar